| http://purl.uniprot.org/citations/28082443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28082443 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways is a hallmark of a variety of B-cell lymphomas, including classical Hodgkin lymphoma (cHL). Constitutive JAK/STAT signaling is crucial for survival and proliferation of Hodgkin/Reed-Sternberg (HRS) cells, the malignant cells of cHL. Although the molecular basis of this constitutive JAK/STAT signaling in cHL has not been completely understood, accumulating reports highlight the role of an inactivation or reduced expression of negative JAK/STAT regulators such as silencer of cell signaling 1 (SOCS1) or protein-tyrosine phosphatase 1B (PTP1B) in this process. Here, we report the expression of truncated PTP1B mRNA variants identified in cHL cell lines and primary cHL tumor samples lacking either 1 or several exon sequences. One of these novel PTP1B variants, a splice variant lacking exon 6 (PTP1BΔ6), was found expressed at low levels in cHL cell lines. However, serum stimulation of cHL augmented the expression of PTP1BΔ6 significantly. Functional characterization of PTP1BΔ6 revealed a positive effect on interferon-γ- and interleukin-4-induced JAK/STAT activity in HEK293 or HEK293-STAT6 cells, and on the basal STAT activity in stably transfected L-428 and U-HO1 cHL cell lines. Furthermore, PTP1BΔ6 expression increased the proliferation of L-428 and U-HO1 cells and reduced cytotoxic effects of the chemotherapeutical agents gemcitabine and etoposide distinctively. Collectively, these data indicate that PTP1BΔ6 is a positive regulator of JAK/STAT signaling in cHL."xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2016-06-720516"xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/author | "Wegener S."xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/author | "Zahn M."xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/author | "Heinrich J."xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/author | "Renner B."xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/author | "Moller P."xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/author | "Marienfeld R."xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/author | "Barth T.F."xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/author | "Bruderlein S."xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/author | "Dorsch K."xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/author | "Melzner I."xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/author | "Miessner A."xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/pages | "1480-1490"xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/title | "A novel PTPN1 splice variant upregulates JAK/STAT activity in classical Hodgkin lymphoma cells."xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://purl.uniprot.org/core/volume | "129"xsd:string |
| http://purl.uniprot.org/citations/28082443 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28082443 |
| http://purl.uniprot.org/citations/28082443 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28082443 |
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| http://purl.uniprot.org/uniprot/#_B4DSN5-mappedCitation-28082443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28082443 |
| http://purl.uniprot.org/uniprot/#_P18031-mappedCitation-28082443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28082443 |
| http://purl.uniprot.org/uniprot/#_Q96QT9-mappedCitation-28082443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28082443 |