| http://purl.uniprot.org/citations/28085150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28085150 | http://www.w3.org/2000/01/rdf-schema#comment | "The pro-survival proteins of the BCL-2 family regulate the survival of all cells, and genetic deletion models for these proteins have revealed which specific BCL-2 family member(s) is/are critical for the survival of particular cell types. A1 is a pro-survival BCL-2-like protein that is expressed predominantly in haematopoietic cells, and here we describe the characterisation of a novel mouse strain that lacks all three functional isoforms of A1 (A1-a, A1-b and A1-d). Surprisingly, complete loss of A1 caused only minor defects, with significant, although relatively small, decreases in γδTCR T cells, antigen-experienced conventional as well as regulatory CD4 T cells and conventional dendritic cells (cDCs). When examining these cell types in tissue culture, only cDC survival was significantly impaired by the loss of A1. Therefore, A1 appears to be a surprisingly redundant pro-survival protein in the haematopoietic system and other tissues, suggesting that its targeting in cancer may be readily tolerated."xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2016.156"xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/author | "Zhan Y."xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/author | "Lew A.M."xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/author | "Tai L."xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/author | "Strasser A."xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/author | "Villunger A."xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/author | "Herold M.J."xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/author | "Teh C.E."xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/author | "Gray D.H."xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/author | "Heinzel S."xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/author | "Carrington E.M."xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/author | "Tuzlak S."xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/author | "Schenk R.L."xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/pages | "534-545"xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/title | "Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment."xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/28085150 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28085150 |
| http://purl.uniprot.org/citations/28085150 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28085150 |
| http://purl.uniprot.org/uniprot/#_O55177-mappedCitation-28085150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28085150 |
| http://purl.uniprot.org/uniprot/#_O55179-mappedCitation-28085150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28085150 |
| http://purl.uniprot.org/uniprot/#_Q07440-mappedCitation-28085150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28085150 |