| http://purl.uniprot.org/citations/28087685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28087685 | http://www.w3.org/2000/01/rdf-schema#comment | "BST-2 (tetherin, CD317, and HM1.24) is induced by interferon and restricts virus release by tethering the enveloped viruses to the cell surface. The effect of BST-2 on influenza A virus (IAV) infection has been inconclusive. In the present study, we report that BST-2 diminishes the production of IAV virus-like particles (VLPs) that are generated by viral neuraminidase and hemagglutinin proteins to a much greater degree than it inhibits the production of wild-type IAV particles. This relatively weaker inhibition of IAV is associated with reduction in BST-2 levels, which is caused by the M2 protein that interacts with BST-2 and leads to down-regulation of cell surface BST-2 via the proteasomal pathway. Similarly to the viral antagonist Vpu, M2 also rescues the production of human immunodeficiency virus-1 VLPs and IAV VLPs in the presence of BST-2. Replication of wild-type and the M2-deleted viruses were both inhibited by BST-2, with the M2-deleted IAV being more restricted. These data reveal one mechanism that IAV employs to counter restriction by BST-2."xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.org/dc/terms/identifier | "doi:10.1042/bcj20160861"xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/author | "Hu S."xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/author | "Li A."xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/author | "Guo F."xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/author | "Liang C."xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/author | "Sun H."xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/author | "Xu F."xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/author | "Cen S."xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/author | "Mei S."xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/author | "Yin L."xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/pages | "715-730"xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/title | "BST-2 restricts IAV release and is countered by the viral M2 protein."xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://purl.uniprot.org/core/volume | "474"xsd:string |
| http://purl.uniprot.org/citations/28087685 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28087685 |
| http://purl.uniprot.org/citations/28087685 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28087685 |
| http://purl.uniprot.org/uniprot/#_A0A024R7H5-mappedCitation-28087685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28087685 |
| http://purl.uniprot.org/uniprot/#_B4E0Z6-mappedCitation-28087685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28087685 |
| http://purl.uniprot.org/uniprot/#_Q10589-mappedCitation-28087685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28087685 |
| http://purl.uniprot.org/uniprot/#_Q7Z5Z8-mappedCitation-28087685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28087685 |