| http://purl.uniprot.org/citations/28088441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28088441 | http://www.w3.org/2000/01/rdf-schema#comment | "Resveratrol (RESV) is a natural polyphenolic compound endowed with anti-inflammatory, anti-proliferative, as well as pro-apoptotic activities that make it a potential anti-tumor compound. Here we show that RESV counteracts the TGF-β-induced Epithelial to Mesenchymal Transition (EMT) phenotype in mammary gland cells and affects the alternative exon usage of pre-mRNAs that encode crucial factors in adhesion and migration -including CD44, ENAH, and FGFR2-in a panel of immortalized and transformed mammary gland cells. RESV causes a shift from the mesenchymal-specific forms of these factors to the respective epithelial forms and increases the expression of the RNA-binding proteins KHSRP and hnRNPA1. From a mechanistic point of view, we show that the combined silencing of KHSRP and hnRNPA1 prevents the RESV-dependent inclusion of the epithelial-type exons in the Cd44 pre-mRNA. Our findings support an unexpected regulatory mechanism where RESV limits EMT by controlling gene expression at post-transcriptional level."xsd:string |
| http://purl.uniprot.org/citations/28088441 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbagrm.2017.01.001"xsd:string |
| http://purl.uniprot.org/citations/28088441 | http://purl.uniprot.org/core/author | "Gherzi R."xsd:string |
| http://purl.uniprot.org/citations/28088441 | http://purl.uniprot.org/core/author | "Rossi M."xsd:string |
| http://purl.uniprot.org/citations/28088441 | http://purl.uniprot.org/core/author | "Briata P."xsd:string |
| http://purl.uniprot.org/citations/28088441 | http://purl.uniprot.org/core/author | "Moshiri A."xsd:string |
| http://purl.uniprot.org/citations/28088441 | http://purl.uniprot.org/core/author | "Puppo M."xsd:string |
| http://purl.uniprot.org/citations/28088441 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28088441 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta Gene Regul Mech"xsd:string |
| http://purl.uniprot.org/citations/28088441 | http://purl.uniprot.org/core/pages | "291-298"xsd:string |
| http://purl.uniprot.org/citations/28088441 | http://purl.uniprot.org/core/title | "Resveratrol limits epithelial to mesenchymal transition through modulation of KHSRP/hnRNPA1-dependent alternative splicing in mammary gland cells."xsd:string |
| http://purl.uniprot.org/citations/28088441 | http://purl.uniprot.org/core/volume | "1860"xsd:string |
| http://purl.uniprot.org/citations/28088441 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28088441 |
| http://purl.uniprot.org/citations/28088441 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28088441 |
| http://purl.uniprot.org/uniprot/#_P70370-mappedCitation-28088441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28088441 |
| http://purl.uniprot.org/uniprot/#_Q3U0V1-mappedCitation-28088441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28088441 |
| http://purl.uniprot.org/uniprot/#_P49312-mappedCitation-28088441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28088441 |
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| http://purl.uniprot.org/uniprot/#_Q3TIK8-mappedCitation-28088441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28088441 |
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| http://purl.uniprot.org/uniprot/#_Q3UK83-mappedCitation-28088441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28088441 |
| http://purl.uniprot.org/uniprot/#_Q5EBP8-mappedCitation-28088441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28088441 |
| http://purl.uniprot.org/uniprot/#_Q8CEN4-mappedCitation-28088441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28088441 |
| http://purl.uniprot.org/uniprot/#_Q9R1J3-mappedCitation-28088441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28088441 |