| http://purl.uniprot.org/citations/28088699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28088699 | http://www.w3.org/2000/01/rdf-schema#comment | "Procyanidins are widely found in plants and have anti-inflammatory activities. Procyanidin B2 (PCB2) inhibits production of proinflammatory cytokines in macrophages. However, there has been no study that has attempted to determine the effects of PCB2 gallates on T cell functions. In the present study, murine splenocytes were isolated and treated with PCB2 or PCB2 gallates in the presence of an anti-CD3 monoclonal antibody (mAb). PCB2 gallates, but not PCB2, inhibited proliferation and T cell activation of splenocytes after stimulation with the anti-CD3 mAb. In addition, PCB2 gallates, particularly 3,3″-di-O-gallate (3,3″-di-OG), significantly inhibited production of interferon (IFN)-γ, interleukin (IL)-12p40, and IL-17 in splenocytes, but did not suppress IL-10 production. Intracellular staining revealed that the expression of IFN-γ and IL-17 in both CD4+ and CD8+ T cells was obviously decreased by PCB2 3,3″-di-OG compared with PCB2, PCB2 3-OG, and PCB2 3″-OG. Treatment of isolated CD4+ and CD8+ T cells with procyanidins in the presence of the anti-CD3 mAb led to significant inhibition of IFN-γ production by PCB2 3,3″-di-OG in both cell types. Furthermore, PCB2 3,3″-di-OG suppressed the expression of transcription factors T-bet and RORγt that regulate IFN-γ and IL-17, respectively. In conclusion, we revealed a new mechanism through which PCB2 gallates inhibit IFN-γ and IL-17 production in T cells by down-regulation of T-bet and RORγt expression. Our results suggest that PCB2 gallates have a potential role in Th1/Th17-mediated diseases such as inflammatory and autoimmune diseases."xsd:string |
| http://purl.uniprot.org/citations/28088699 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.intimp.2017.01.007"xsd:string |
| http://purl.uniprot.org/citations/28088699 | http://purl.uniprot.org/core/author | "Furuya K."xsd:string |
| http://purl.uniprot.org/citations/28088699 | http://purl.uniprot.org/core/author | "Ichikawa M."xsd:string |
| http://purl.uniprot.org/citations/28088699 | http://purl.uniprot.org/core/author | "Tanaka S."xsd:string |
| http://purl.uniprot.org/citations/28088699 | http://purl.uniprot.org/core/author | "Yamada K."xsd:string |
| http://purl.uniprot.org/citations/28088699 | http://purl.uniprot.org/core/author | "Yamamoto K."xsd:string |
| http://purl.uniprot.org/citations/28088699 | http://purl.uniprot.org/core/author | "Suda M."xsd:string |
| http://purl.uniprot.org/citations/28088699 | http://purl.uniprot.org/core/author | "Makabe H."xsd:string |
| http://purl.uniprot.org/citations/28088699 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28088699 | http://purl.uniprot.org/core/name | "Int Immunopharmacol"xsd:string |
| http://purl.uniprot.org/citations/28088699 | http://purl.uniprot.org/core/pages | "87-96"xsd:string |
| http://purl.uniprot.org/citations/28088699 | http://purl.uniprot.org/core/title | "Procyanidin B2 gallates inhibit IFN-gamma and IL-17 production in T cells by suppressing T-bet and RORgammat expression."xsd:string |
| http://purl.uniprot.org/citations/28088699 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/28088699 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28088699 |
| http://purl.uniprot.org/citations/28088699 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28088699 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGZ6-mappedCitation-28088699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28088699 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J096-mappedCitation-28088699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28088699 |
| http://purl.uniprot.org/uniprot/#_Q3UUW3-mappedCitation-28088699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28088699 |
| http://purl.uniprot.org/uniprot/#_Q5PSB0-mappedCitation-28088699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28088699 |
| http://purl.uniprot.org/uniprot/#_P51450-mappedCitation-28088699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28088699 |
| http://purl.uniprot.org/uniprot/#_Q3TVH3-mappedCitation-28088699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28088699 |
| http://purl.uniprot.org/uniprot/#_Q9JKD8-mappedCitation-28088699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28088699 |
| http://purl.uniprot.org/uniprot/Q9JKD8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28088699 |