| http://purl.uniprot.org/citations/28089248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28089248 | http://www.w3.org/2000/01/rdf-schema#comment | "Sensing of nucleic acids by pattern recognition receptors is the key for the initiation and development of systemic lupus erythematosus (SLE). Triggering receptor expressed on myeloid cells-1 (TREM-1) is a novel innate immune receptor, which can amplify Toll-like receptor (TLR)-induced inflammatory responses. Although patients with lupus exhibit increased serum levels of soluble TREM-1 (sTREM-1), the role of TREM-1 in SLE remains unknown. In current study, we found serum sTREM-1 levels were significantly increased in lupus patients and positively correlated with disease activity. Additionally, diseased B6.lpr mice had elevated TREM-1 in the serum, spleen, and lymph nodes. To investigate the role of TREM-1 in lupus, we established Trem-1-/-.lpr mice. Trem-1-/-.lpr mice exhibited lower survival rates and more severe lupus symptoms, including elevated proteinuria, serum anti-dsDNA antibody levels, renal immune complex depositions and lymphocyte subpopulation expansions in both the spleen and lymph nodes. Besides, Trem-1-/-.lpr mice expressed higher serum B cell-activating factor (BAFF) levels and lymph node dendritic cells (DCs) were the major source of increased BAFF. Activation of membrane-bound TREM-1 could suppress TLR9-induced BAFF expression in bone marrow-derived DCs of B6.lpr mice. Moreover, levels of sTREM-1, which could act as an antagonist of membrane-bound TREM-1, were positively correlated with levels of BAFF in the sera of lupus patients. Our findings suggest a novel modulatory role of TREM-1 in the pathogenesis of SLE. sTREM-1 production is a useful diagnostic marker and a molecular target for combination therapy of lupus."xsd:string |
| http://purl.uniprot.org/citations/28089248 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jaut.2016.12.010"xsd:string |
| http://purl.uniprot.org/citations/28089248 | http://purl.uniprot.org/core/author | "Tang S.J."xsd:string |
| http://purl.uniprot.org/citations/28089248 | http://purl.uniprot.org/core/author | "Mak T.W."xsd:string |
| http://purl.uniprot.org/citations/28089248 | http://purl.uniprot.org/core/author | "Sun G.H."xsd:string |
| http://purl.uniprot.org/citations/28089248 | http://purl.uniprot.org/core/author | "Liu C.J."xsd:string |
| http://purl.uniprot.org/citations/28089248 | http://purl.uniprot.org/core/author | "Sun K.H."xsd:string |
| http://purl.uniprot.org/citations/28089248 | http://purl.uniprot.org/core/author | "Chiang S.H."xsd:string |
| http://purl.uniprot.org/citations/28089248 | http://purl.uniprot.org/core/author | "Tsai C.Y."xsd:string |
| http://purl.uniprot.org/citations/28089248 | http://purl.uniprot.org/core/author | "Chen N.J."xsd:string |
| http://purl.uniprot.org/citations/28089248 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28089248 | http://purl.uniprot.org/core/name | "J Autoimmun"xsd:string |
| http://purl.uniprot.org/citations/28089248 | http://purl.uniprot.org/core/pages | "92-100"xsd:string |
| http://purl.uniprot.org/citations/28089248 | http://purl.uniprot.org/core/title | "Triggering receptor expressed on myeloid cells-1 (TREM-1) deficiency augments BAFF production to promote lupus progression."xsd:string |
| http://purl.uniprot.org/citations/28089248 | http://purl.uniprot.org/core/volume | "78"xsd:string |
| http://purl.uniprot.org/citations/28089248 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28089248 |
| http://purl.uniprot.org/citations/28089248 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28089248 |
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| http://purl.uniprot.org/uniprot/#_Q14DT9-mappedCitation-28089248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28089248 |
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| http://purl.uniprot.org/uniprot/#_K7EKM5-mappedCitation-28089248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28089248 |