| http://purl.uniprot.org/citations/28092921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28092921 | http://www.w3.org/2000/01/rdf-schema#comment | "Normal epithelial cells often exert anti-tumour effects against nearby oncogenic cells. In the Drosophila imaginal epithelium, clones of oncogenic cells with loss-of-function mutations in the apico-basal polarity genes scribble or discs large are actively eliminated by cell competition when surrounded by wild-type cells. Although c-Jun N-terminal kinase (JNK) signalling plays a crucial role in this cell elimination, the initial event, which occurs at the interface between normal cells and polarity-deficient cells, has not previously been identified. Here, through a genetic screen in Drosophila, we identify the ligand Sas and the receptor-type tyrosine phosphatase PTP10D as the cell-surface ligand-receptor system that drives tumour-suppressive cell competition. At the interface between the wild-type 'winner' and the polarity-deficient 'loser' clones, winner cells relocalize Sas to the lateral cell surface, whereas loser cells relocalize PTP10D there. This leads to the trans-activation of Sas-PTP10D signalling in loser cells, which restrains EGFR signalling and thereby enables elevated JNK signalling in loser cells, triggering cell elimination. In the absence of Sas-PTP10D, elevated EGFR signalling in loser cells switches the role of JNK from pro-apoptotic to pro-proliferative by inactivating the Hippo pathway, thereby driving the overgrowth of polarity-deficient cells. These findings uncover the mechanism by which normal epithelial cells recognize oncogenic polarity-deficient neighbours to drive cell competition."xsd:string |
| http://purl.uniprot.org/citations/28092921 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature21033"xsd:string |
| http://purl.uniprot.org/citations/28092921 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/28092921 | http://purl.uniprot.org/core/author | "Igaki T."xsd:string |
| http://purl.uniprot.org/citations/28092921 | http://purl.uniprot.org/core/author | "Ohsawa S."xsd:string |
| http://purl.uniprot.org/citations/28092921 | http://purl.uniprot.org/core/author | "Kunimasa K."xsd:string |
| http://purl.uniprot.org/citations/28092921 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28092921 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/28092921 | http://purl.uniprot.org/core/pages | "246-250"xsd:string |
| http://purl.uniprot.org/citations/28092921 | http://purl.uniprot.org/core/title | "The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition."xsd:string |
| http://purl.uniprot.org/citations/28092921 | http://purl.uniprot.org/core/volume | "542"xsd:string |
| http://purl.uniprot.org/citations/28092921 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28092921 |
| http://purl.uniprot.org/citations/28092921 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28092921 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFQ6-mappedCitation-28092921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28092921 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFQ8-mappedCitation-28092921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28092921 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KG15-mappedCitation-28092921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28092921 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHN3-mappedCitation-28092921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28092921 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS1-mappedCitation-28092921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28092921 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHY2-mappedCitation-28092921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28092921 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEQ8-mappedCitation-28092921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28092921 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEV2-mappedCitation-28092921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28092921 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHD4-mappedCitation-28092921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28092921 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KI37-mappedCitation-28092921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28092921 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LEH1-mappedCitation-28092921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28092921 |