http://purl.uniprot.org/citations/28093084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/28093084 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundChemotherapy toxicity is a serious problem from which non-small cell lung cancer (NSCLC) patients suffer. The mismatch repair (MMR) system is associated with platinum-based chemotherapy toxicity in NSCLC patients. In this study, we aimed to investigate the relationship between genetic polymorphisms in the MMR pathway and platinum-based chemotherapy toxicity in NSCLC patients.MethodsA total of 220 Chinese lung cancer patients who received at least two cycles of platinum-based chemotherapy were recruited for this study. Toxicity was evaluated in each patient after two cycles of chemotherapy. A total of 44 single nucleotide polymorphisms were selected to investigate their associations with platinum-based chemotherapy toxicity.ResultsMutS homolog 2 (MSH2) rs6544991 [odds ratio (OR) 2.98, 95% confidence interval (CI) 1.20-7.40, P = 0.019] was associated with gastrointestinal toxicity in the dominant model; MSH3 rs6151627 (OR 2.38, 95% CI 1.23-4.60, P = 0.010), rs6151670 (OR 2.05, 95% CI 1.07-3.93, P = 0.031), and rs7709909 (OR 2.38, 95% CI 1.23-4.64, P = 0.010) were associated with hematologic toxicity in the dominant model. Additionally, MSH5 rs805304 was significantly associated with overall toxicity (OR 2.21, 95% CI 1.19-4.09, P = 0.012), and MSH5 rs707939 was significantly associated with both overall toxicity (OR 0.42, 95% CI 0.23-0.76, P = 0.004) and gastrointestinal toxicity (OR 0.44, 95% CI 0.20-0.96, P = 0.038) in the dominant model.ConclusionGenetic polymorphisms in the MMR pathway are potential clinical markers for predicting chemotherapy toxicity in NSCLC patients."xsd:string |
http://purl.uniprot.org/citations/28093084 | http://purl.org/dc/terms/identifier | "doi:10.1186/s40880-016-0175-2"xsd:string |
http://purl.uniprot.org/citations/28093084 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
http://purl.uniprot.org/citations/28093084 | http://purl.uniprot.org/core/author | "Liu J.Y."xsd:string |
http://purl.uniprot.org/citations/28093084 | http://purl.uniprot.org/core/author | "Gao Y.F."xsd:string |
http://purl.uniprot.org/citations/28093084 | http://purl.uniprot.org/core/author | "Zhou H.H."xsd:string |
http://purl.uniprot.org/citations/28093084 | http://purl.uniprot.org/core/author | "Yin J.Y."xsd:string |
http://purl.uniprot.org/citations/28093084 | http://purl.uniprot.org/core/author | "Qian C.Y."xsd:string |
http://purl.uniprot.org/citations/28093084 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
http://purl.uniprot.org/citations/28093084 | http://purl.uniprot.org/core/name | "Chin J Cancer"xsd:string |
http://purl.uniprot.org/citations/28093084 | http://purl.uniprot.org/core/pages | "12"xsd:string |
http://purl.uniprot.org/citations/28093084 | http://purl.uniprot.org/core/title | "Association between DNA mismatch repair gene polymorphisms and platinum-based chemotherapy toxicity in non-small cell lung cancer patients."xsd:string |
http://purl.uniprot.org/citations/28093084 | http://purl.uniprot.org/core/volume | "36"xsd:string |
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