| http://purl.uniprot.org/citations/28094768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28094768 | http://www.w3.org/2000/01/rdf-schema#comment | "Compromised apoptotic signaling is a prerequisite for tumorigenesis. The design of effective therapies for cancer treatment depends on a comprehensive understanding of the mechanisms that govern cell survival. The antiapoptotic proteins of the BCL-2 family are key regulators of cell survival and are frequently overexpressed in malignancies, leading to increased cancer cell survival. Unlike BCL-2 and BCL-XL, the closest antiapoptotic relative BCL-W is required for spermatogenesis, but was considered dispensable for all other cell types. Here, however, we have exposed a critical role for BCL-W in B cell survival and lymphomagenesis. Loss of Bcl-w conferred sensitivity to growth factor deprivation-induced B cell apoptosis. Moreover, Bcl-w loss profoundly delayed MYC-mediated B cell lymphoma development due to increased MYC-induced B cell apoptosis. We also determined that MYC regulates BCL-W expression through its transcriptional regulation of specific miR. BCL-W expression was highly selected for in patient samples of Burkitt lymphoma (BL), with 88.5% expressing BCL-W. BCL-W knockdown in BL cell lines induced apoptosis, and its overexpression conferred resistance to BCL-2 family-targeting BH3 mimetics. Additionally, BCL-W was overexpressed in diffuse large B cell lymphoma and correlated with decreased patient survival. Collectively, our results reveal that BCL-W profoundly contributes to B cell lymphoma, and its expression could serve as a biomarker for diagnosis and aid in the development of better targeted therapies."xsd:string |
| http://purl.uniprot.org/citations/28094768 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci89486"xsd:string |
| http://purl.uniprot.org/citations/28094768 | http://purl.uniprot.org/core/author | "Choi J.K."xsd:string |
| http://purl.uniprot.org/citations/28094768 | http://purl.uniprot.org/core/author | "Kim A.S."xsd:string |
| http://purl.uniprot.org/citations/28094768 | http://purl.uniprot.org/core/author | "Eischen C.M."xsd:string |
| http://purl.uniprot.org/citations/28094768 | http://purl.uniprot.org/core/author | "Mitra R."xsd:string |
| http://purl.uniprot.org/citations/28094768 | http://purl.uniprot.org/core/author | "Adams C.M."xsd:string |
| http://purl.uniprot.org/citations/28094768 | http://purl.uniprot.org/core/author | "Gong J.Z."xsd:string |
| http://purl.uniprot.org/citations/28094768 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28094768 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/28094768 | http://purl.uniprot.org/core/pages | "635-650"xsd:string |
| http://purl.uniprot.org/citations/28094768 | http://purl.uniprot.org/core/title | "BCL-W has a fundamental role in B cell survival and lymphomagenesis."xsd:string |
| http://purl.uniprot.org/citations/28094768 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/28094768 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28094768 |
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