| http://purl.uniprot.org/citations/2809592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2809592 | http://www.w3.org/2000/01/rdf-schema#comment | "A soluble form of the neural cell adhesion molecule (N-CAM) was obtained from 100,000-g supernatants of crude brain membrane fractions by incubation for 2 h at 37 degrees C. The isolated N-CAM, consisting of one polypeptide chain with a molecular mass of 110 kilodaltons (N-CAM 110), was studied for its binding specificity to different components of the extracellular matrix (ECM). N-CAM 110 bound to different types of collagen (collagen types I-VI and IX). The binding efficiency was dependent on salt concentration and could be called specific according to the following criteria: (a) Binding showed substrate specificity (binding to collagens, but not to other ECM components, such as laminin or fibronectin). (b) Binding of N-CAM 110 to heat-denatured collagens was absent or substantially reduced. (c) Binding was saturable (Scatchard plot analyses were linear with KD values in the range of 9.3-2.0 X 10(-9) M, depending on the collagen type and buffer conditions). Binding of N-CAM 110 to collagens could be prevented in a concentration-dependent manner by the glycosaminoglycans heparin and chondroitin sulfate. N-CAM 110 also interacted with immobilized heparin, and this interaction could be prevented by heparin and chondroitin sulfate. Thus, in addition to its role in cell-cell adhesion, N-CAM is a binding partner for different ECM components, an observation suggesting that it also serves as a substrate adhesion molecule in vivo."xsd:string |
| http://purl.uniprot.org/citations/2809592 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.1989.tb09245.x"xsd:string |
| http://purl.uniprot.org/citations/2809592 | http://purl.uniprot.org/core/author | "Schachner M."xsd:string |
| http://purl.uniprot.org/citations/2809592 | http://purl.uniprot.org/core/author | "Kuhn K."xsd:string |
| http://purl.uniprot.org/citations/2809592 | http://purl.uniprot.org/core/author | "Probstmeier R."xsd:string |
| http://purl.uniprot.org/citations/2809592 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2809592 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/2809592 | http://purl.uniprot.org/core/pages | "1794-1801"xsd:string |
| http://purl.uniprot.org/citations/2809592 | http://purl.uniprot.org/core/title | "Binding properties of the neural cell adhesion molecule to different components of the extracellular matrix."xsd:string |
| http://purl.uniprot.org/citations/2809592 | http://purl.uniprot.org/core/volume | "53"xsd:string |
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