| http://purl.uniprot.org/citations/28096424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28096424 | http://www.w3.org/2000/01/rdf-schema#comment | "Stable anchoring of titin within the muscle Z-disk is essential for preserving muscle integrity during passive stretching. One of the main candidates for anchoring titin in the Z-disk is the actin cross-linker α-actinin. The calmodulin-like domain of α-actinin binds to the Z-repeats of titin. However, the mechanical and kinetic properties of this important interaction are still unknown. Here, we use a dual-beam optical tweezers assay to study the mechanics of this interaction at the single-molecule level. A single interaction of α-actinin and titin turns out to be surprisingly weak if force is applied. Depending on the direction of force application, the unbinding forces can more than triple. Our results suggest a model where multiple α-actinin/Z-repeat interactions cooperate to ensure long-term stable titin anchoring while allowing the individual components to exchange dynamically."xsd:string |
| http://purl.uniprot.org/citations/28096424 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1612681114"xsd:string |
| http://purl.uniprot.org/citations/28096424 | http://purl.uniprot.org/core/author | "Djinovic-Carugo K."xsd:string |
| http://purl.uniprot.org/citations/28096424 | http://purl.uniprot.org/core/author | "Kostan J."xsd:string |
| http://purl.uniprot.org/citations/28096424 | http://purl.uniprot.org/core/author | "Grison M."xsd:string |
| http://purl.uniprot.org/citations/28096424 | http://purl.uniprot.org/core/author | "Rief M."xsd:string |
| http://purl.uniprot.org/citations/28096424 | http://purl.uniprot.org/core/author | "Merkel U."xsd:string |
| http://purl.uniprot.org/citations/28096424 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28096424 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/28096424 | http://purl.uniprot.org/core/pages | "1015-1020"xsd:string |
| http://purl.uniprot.org/citations/28096424 | http://purl.uniprot.org/core/title | "alpha-Actinin/titin interaction: A dynamic and mechanically stable cluster of bonds in the muscle Z-disk."xsd:string |
| http://purl.uniprot.org/citations/28096424 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/28096424 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28096424 |
| http://purl.uniprot.org/citations/28096424 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28096424 |
| http://purl.uniprot.org/uniprot/#_A0A7R6M6R8-mappedCitation-28096424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28096424 |
| http://purl.uniprot.org/uniprot/#_A0A7R6M6U5-mappedCitation-28096424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28096424 |
| http://purl.uniprot.org/uniprot/#_A0A7R6M8F2-mappedCitation-28096424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28096424 |
| http://purl.uniprot.org/uniprot/#_A0A7R6M8N0-mappedCitation-28096424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28096424 |
| http://purl.uniprot.org/uniprot/#_A0A7R6M8N3-mappedCitation-28096424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28096424 |
| http://purl.uniprot.org/uniprot/#_B7Z4K1-mappedCitation-28096424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28096424 |
| http://purl.uniprot.org/uniprot/#_B7Z4P6-mappedCitation-28096424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28096424 |
| http://purl.uniprot.org/uniprot/#_B7Z4P8-mappedCitation-28096424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28096424 |
| http://purl.uniprot.org/uniprot/#_B7Z4V1-mappedCitation-28096424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28096424 |
| http://purl.uniprot.org/uniprot/#_B7Z2N5-mappedCitation-28096424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28096424 |