| http://purl.uniprot.org/citations/28098138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28098138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28098138 | http://www.w3.org/2000/01/rdf-schema#comment | "Danger signals activate Toll-like receptors (TLRs), thereby initiating inflammatory responses. Canonical TLR signalling, via Toll/Interleukin-1 receptor domain (TIR)-containing adaptors and proinflammatory transcription factors such as NF-κB, occurs in many cell types; however, additional mechanisms are required for specificity of inflammatory responses in innate immune cells. Here we show that SCIMP, an immune-restricted, transmembrane adaptor protein (TRAP), promotes selective proinflammatory cytokine responses by direct modulation of TLR4. SCIMP is a non-TIR-containing adaptor, binding directly to the TLR4-TIR domain in response to lipopolysaccharide. In macrophages, SCIMP is constitutively associated with the Lyn tyrosine kinase, is required for tyrosine phosphorylation of TLR4, and facilitates TLR-inducible production of the proinflammatory cytokines IL-6 and IL-12p40. Point mutations in SCIMP abrogating TLR4 binding also prevent SCIMP-mediated cytokine production. SCIMP is, therefore, an immune-specific TLR adaptor that shapes host defence and inflammation."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms14133"xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms14133"xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Guo Z."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Guo Z."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Luo L."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Luo L."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Ross I.L."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Ross I.L."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Sweet M.J."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Sweet M.J."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Stow J.L."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Stow J.L."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Tong S.J."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Tong S.J."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Wall A.A."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Wall A.A."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Alexandrov K."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Alexandrov K."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Hibbs M.L."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Hibbs M.L."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Bokil N.J."xsd:string |
| http://purl.uniprot.org/citations/28098138 | http://purl.uniprot.org/core/author | "Bokil N.J."xsd:string |