| http://purl.uniprot.org/citations/28100774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28100774 | http://www.w3.org/2000/01/rdf-schema#comment | "The failure of pancreatic islet β-cells is a major contributor to the etiology of type 2 diabetes. β-Cell dysfunction and declining β-cell mass are two mechanisms that contribute to this failure, although it is unclear whether they are molecularly linked. Here, we show that the cell cycle regulator, cyclin-dependent kinase 2 (CDK2), couples primary β-cell dysfunction to the progressive deterioration of β-cell mass in diabetes. Mice with pancreas-specific deletion of Cdk2 are glucose-intolerant, primarily due to defects in glucose-stimulated insulin secretion. Accompanying this loss of secretion are defects in β-cell metabolism and perturbed mitochondrial structure. Persistent insulin secretion defects culminate in progressive deficits in β-cell proliferation, reduced β-cell mass, and diabetes. These outcomes may be mediated directly by the loss of CDK2, which binds to and phosphorylates the transcription factor FOXO1 in a glucose-dependent manner. Further, we identified a requirement for CDK2 in the compensatory increases in β-cell mass that occur in response to age- and diet-induced stress. Thus, CDK2 serves as an important nexus linking primary β-cell dysfunction to progressive β-cell mass deterioration in diabetes."xsd:string |
| http://purl.uniprot.org/citations/28100774 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m116.754077"xsd:string |
| http://purl.uniprot.org/citations/28100774 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/28100774 | http://purl.uniprot.org/core/author | "Kim S.Y."xsd:string |
| http://purl.uniprot.org/citations/28100774 | http://purl.uniprot.org/core/author | "Gavrilova O."xsd:string |
| http://purl.uniprot.org/citations/28100774 | http://purl.uniprot.org/core/author | "Rane S.G."xsd:string |
| http://purl.uniprot.org/citations/28100774 | http://purl.uniprot.org/core/author | "Kaldis P."xsd:string |
| http://purl.uniprot.org/citations/28100774 | http://purl.uniprot.org/core/author | "Bisteau X."xsd:string |
| http://purl.uniprot.org/citations/28100774 | http://purl.uniprot.org/core/author | "Satin L.S."xsd:string |
| http://purl.uniprot.org/citations/28100774 | http://purl.uniprot.org/core/author | "Merrins M.J."xsd:string |
| http://purl.uniprot.org/citations/28100774 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28100774 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/28100774 | http://purl.uniprot.org/core/pages | "3841-3853"xsd:string |
| http://purl.uniprot.org/citations/28100774 | http://purl.uniprot.org/core/title | "Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary beta-Cell Dysfunction to Progressive Depletion of beta-Cell Mass and Diabetes."xsd:string |
| http://purl.uniprot.org/citations/28100774 | http://purl.uniprot.org/core/volume | "292"xsd:string |
| http://purl.uniprot.org/citations/28100774 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28100774 |
| http://purl.uniprot.org/citations/28100774 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28100774 |
| http://purl.uniprot.org/uniprot/#_D3Z595-mappedCitation-28100774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28100774 |
| http://purl.uniprot.org/uniprot/#_D3Z596-mappedCitation-28100774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28100774 |
| http://purl.uniprot.org/uniprot/#_E0CXX7-mappedCitation-28100774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28100774 |
| http://purl.uniprot.org/uniprot/#_D3YWU5-mappedCitation-28100774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28100774 |
| http://purl.uniprot.org/uniprot/#_P52792-mappedCitation-28100774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28100774 |
| http://purl.uniprot.org/uniprot/#_P52946-mappedCitation-28100774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28100774 |
| http://purl.uniprot.org/uniprot/#_P56501-mappedCitation-28100774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28100774 |