| http://purl.uniprot.org/citations/28101297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28101297 | http://www.w3.org/2000/01/rdf-schema#comment | "Background and Aims. Angiotensin converting enzyme 2 (ACE2) is an important component of the renin-angiotensin system. Since angiotensin peptides have been shown to be involved in hepatic steatosis, we aimed to evaluate the hepatic lipid profile in ACE2-deficient (ACE2-/y) mice. Methods. Male C57BL/6 and ACE2-/y mice were analyzed at the age of 3 and 6 months for alterations in the lipid profiles of plasma, faeces, and liver and for hepatic steatosis. Results. ACE2-/y mice showed lower body weight and white adipose tissue at all ages investigated. Moreover, these mice had lower levels of cholesterol, triglycerides, and nonesterified fatty acids in plasma. Strikingly, ACE2-/y mice showed high deposition of lipids in the liver. Expression of CD36, a protein involved in the uptake of triglycerides in liver, was increased in ACE2-/y mice. Concurrently, these mice exhibited an increase in hepatic oxidative stress, evidenced by increased lipid peroxidation and expression of uncoupling protein 2, and downregulation of sirtuin 1. ACE2-/y mice also showed impairments in glucose metabolism and insulin signaling in the liver. Conclusions. Deletion of ACE2 causes CD36/sirtuin 1 axis impairment and thereby interferes with lipid homeostasis, leading to lipodystrophy and steatosis."xsd:string |
| http://purl.uniprot.org/citations/28101297 | http://purl.org/dc/terms/identifier | "doi:10.1155/2016/6487509"xsd:string |
| http://purl.uniprot.org/citations/28101297 | http://purl.uniprot.org/core/author | "Bader M."xsd:string |
| http://purl.uniprot.org/citations/28101297 | http://purl.uniprot.org/core/author | "Penninger J.M."xsd:string |
| http://purl.uniprot.org/citations/28101297 | http://purl.uniprot.org/core/author | "Alenina N."xsd:string |
| http://purl.uniprot.org/citations/28101297 | http://purl.uniprot.org/core/author | "Santos R.A."xsd:string |
| http://purl.uniprot.org/citations/28101297 | http://purl.uniprot.org/core/author | "Qadri F."xsd:string |
| http://purl.uniprot.org/citations/28101297 | http://purl.uniprot.org/core/author | "Rabelo L.A."xsd:string |
| http://purl.uniprot.org/citations/28101297 | http://purl.uniprot.org/core/author | "Nunes-Souza V."xsd:string |
| http://purl.uniprot.org/citations/28101297 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/28101297 | http://purl.uniprot.org/core/name | "Oxid Med Cell Longev"xsd:string |
| http://purl.uniprot.org/citations/28101297 | http://purl.uniprot.org/core/pages | "6487509"xsd:string |
| http://purl.uniprot.org/citations/28101297 | http://purl.uniprot.org/core/title | "CD36/Sirtuin 1 Axis Impairment Contributes to Hepatic Steatosis in ACE2-Deficient Mice."xsd:string |
| http://purl.uniprot.org/citations/28101297 | http://purl.uniprot.org/core/volume | "2016"xsd:string |
| http://purl.uniprot.org/citations/28101297 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28101297 |
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