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http://purl.uniprot.org/citations/28104484http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28104484http://www.w3.org/2000/01/rdf-schema#comment"

Background

Familial sick sinus syndrome (SSS) is often attributable to mutations in genes encoding the cardiac Na channel SCN5A and pacemaker channel HCN4. We previously found that SSS with SCN5A mutations shows early onset of manifestations and male predominance. Despite recent reports on the complications of atrial fibrillation (AF) and left ventricular noncompaction (LVNC) in patients with SSS caused by HCN4 mutations, their overall clinical spectrum remains unknown.

Objective

The purpose of this study was to investigate the clinical and demographic features of SSS patients carrying HCN4 mutations.

Methods

We genetically screened 38 unrelated SSS families and functionally analyzed the mutant SCN5A and HCN4 channels by patch clamping. We also evaluated the clinical features of familial SSS by a meta-analysis of 48 SSS probands with mutations in HCN4 (n = 16) and SCN5A (n = 32), including previously reported cases, and 538 sporadic SSS cases.

Results

We identified two HCN4 and three SCN5A loss-of-function mutations in our familial SSS cohort. Meta-analysis of HCN4 mutation carriers showed a significantly younger age at diagnosis (39.1 ± 21.7 years) than in sporadic SSS (74.3 ± 0.4 years; P <.001), but a significantly older age than in SCN5A mutation carriers (20.0 ± 17.6 years; P = .003). Moreover, HCN4 mutation carriers were more frequently associated with AF (43.8%) and LVNC (50%) and with older age at pacemaker implantation (43.5 ± 22.1 years) than were SCN5A mutation carriers (17.8 ± 16.5 years; P <.001).

Conclusion

SSS with HCN4 mutations may form a distinct SSS subgroup characterized by early clinical manifestation after adolescence and frequent association with AF and LVNC."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.org/dc/terms/identifier"doi:10.1016/j.hrthm.2017.01.020"xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Horie M."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Ishikawa T."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Kimoto H."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Murakami T."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Ohno S."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Yoshida K."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Fukuoka T."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Sakamoto R."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Nogami A."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Makita N."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Aiba T."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Shimizu W."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Sumitomo N."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Mishima H."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Yoshiura K.I."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Ohkusa T."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/author"Horigome H."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/name"Heart Rhythm"xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/pages"717-724"xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/title"Sick sinus syndrome with HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular noncompaction."xsd:string
http://purl.uniprot.org/citations/28104484http://purl.uniprot.org/core/volume"14"xsd:string
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