| http://purl.uniprot.org/citations/28105280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28105280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28105280 | http://www.w3.org/2000/01/rdf-schema#comment | "The N-methyl-d-aspartate receptor (NMDAR) is an ionotropic glutamate receptor, gated by the endogenous coagonists glutamate and glycine, permeable to Ca2+ and Na+. NMDAR dysfunction is associated with numerous neurological and psychiatric disorders, including schizophrenia, depression, and Alzheimer's disease. Recently, we have disclosed GNE-0723 (1), a GluN2A subunit-selective and brain-penetrant positive allosteric modulator (PAM) of NMDARs. This work highlights the discovery of a related pyridopyrimidinone core with distinct structure-activity relationships, despite the structural similarity to GNE-0723. GNE-5729 (13), a pyridopyrimidinone-based NMDAR PAM, was identified with both an improved pharmacokinetic profile and increased selectivity against AMPARs. We also include X-ray structure analysis and modeling to propose hypotheses for the activity and selectivity differences."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.org/dc/terms/identifier | "doi:10.1021/acsmedchemlett.6b00388"xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.org/dc/terms/identifier | "doi:10.1021/acsmedchemlett.6b00388"xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Luo X."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Luo X."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Lu A."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Lu A."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Wu G."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Wu G."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Hackos D.H."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Hackos D.H."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Wallweber H.J."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Wallweber H.J."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Ly C.Q."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Ly C.Q."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Tay S."xsd:string |
| http://purl.uniprot.org/citations/28105280 | http://purl.uniprot.org/core/author | "Tay S."xsd:string |