| http://purl.uniprot.org/citations/28114269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28114269 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone metastases remain a serious health concern because of limited therapeutic options. Here, we report that crosstalk between ROR1-HER3 and the Hippo-YAP pathway promotes breast cancer bone metastasis in a long noncoding RNA-dependent fashion. Mechanistically, the orphan receptor tyrosine kinase ROR1 phosphorylates HER3 at a previously unidentified site Tyr1307, following neuregulin stimulation, independently of other ErbB family members. p-HER3 Tyr1307 recruits the LLGL2-MAYA-NSUN6 RNA-protein complex to methylate Hippo/MST1 at Lys59. This methylation leads to MST1 inactivation and activation of YAP target genes in tumour cells, which elicits osteoclast differentiation and bone metastasis. Furthermore, increased ROR1, p-HER3 Tyr1307 and MAYA levels correlate with tumour metastasis and unfavourable outcomes. Our data provide insights into the mechanistic regulation and linkage of the ROR1-HER3 and Hippo-YAP pathway in a cancer-specific context, and also imply valuable therapeutic targets for bone metastasis and possible therapy-resistant tumours."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb3464"xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Hu Q."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Liang H."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Liang K."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Lin C."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Han L."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Lin A."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Yao J."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Hung M.C."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Gallick G.E."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Park P.K."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Xing Z."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/author | "Hawke D.H."xsd:string |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28114269 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |