| http://purl.uniprot.org/citations/28114278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28114278 | http://www.w3.org/2000/01/rdf-schema#comment | "In 11q23 leukemias, the N-terminal part of the mixed lineage leukemia (MLL) gene is fused to >60 different partner genes. In order to define a core set of MLL rearranged targets, we investigated the genome-wide binding of the MLL-AF9 and MLL-AF4 fusion proteins and associated epigenetic signatures in acute myeloid leukemia (AML) cell lines THP-1 and MV4-11. We uncovered both common as well as specific MLL-AF9 and MLL-AF4 target genes, which were all marked by H3K79me2, H3K27ac and H3K4me3. Apart from promoter binding, we also identified MLL-AF9 and MLL-AF4 binding at specific subsets of non-overlapping active distal regulatory elements. Despite this differential enhancer binding, MLL-AF9 and MLL-AF4 still direct a common gene program, which represents part of the RUNX1 gene program and constitutes of CD34+ and monocyte-specific genes. Comparing these data sets identified several zinc finger transcription factors (TFs) as potential MLL-AF9 co-regulators. Together, these results suggest that MLL fusions collaborate with specific subsets of TFs to deregulate the RUNX1 gene program in 11q23 AMLs."xsd:string |
| http://purl.uniprot.org/citations/28114278 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2016.488"xsd:string |
| http://purl.uniprot.org/citations/28114278 | http://purl.uniprot.org/core/author | "Wang S.Y."xsd:string |
| http://purl.uniprot.org/citations/28114278 | http://purl.uniprot.org/core/author | "Stunnenberg H.G."xsd:string |
| http://purl.uniprot.org/citations/28114278 | http://purl.uniprot.org/core/author | "van der Reijden B.A."xsd:string |
| http://purl.uniprot.org/citations/28114278 | http://purl.uniprot.org/core/author | "Kuznetsova T."xsd:string |
| http://purl.uniprot.org/citations/28114278 | http://purl.uniprot.org/core/author | "Marneth A.E."xsd:string |
| http://purl.uniprot.org/citations/28114278 | http://purl.uniprot.org/core/author | "Martens J.H.A."xsd:string |
| http://purl.uniprot.org/citations/28114278 | http://purl.uniprot.org/core/author | "Sotoca A.M."xsd:string |
| http://purl.uniprot.org/citations/28114278 | http://purl.uniprot.org/core/author | "Mandoli A."xsd:string |
| http://purl.uniprot.org/citations/28114278 | http://purl.uniprot.org/core/author | "Prange K.H.M."xsd:string |
| http://purl.uniprot.org/citations/28114278 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28114278 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/28114278 | http://purl.uniprot.org/core/pages | "3346-3356"xsd:string |
| http://purl.uniprot.org/citations/28114278 | http://purl.uniprot.org/core/title | "MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/28114278 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/28114278 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28114278 |
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| http://purl.uniprot.org/uniprot/#_B7Z4N5-mappedCitation-28114278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28114278 |
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