| http://purl.uniprot.org/citations/28115397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28115397 | http://www.w3.org/2000/01/rdf-schema#comment | "Reduced pancreatic β-cell function or mass is the critical problem in developing diabetes. Insulin release from β-cells depends on Ca2+ influx through high voltage-gated Ca2+ channels (HVCCs). Ca2+ influx also regulates insulin synthesis and insulin granule priming and contributes to β-cell electrical activity. The HVCCs are multisubunit protein complexes composed of a pore-forming α1 and auxiliary β and α2δ subunits. α2δ is a key regulator of membrane incorporation and function of HVCCs. Here we show that genetic deletion of α2δ-1, the dominant α2δ subunit in pancreatic islets, results in glucose intolerance and diabetes without affecting insulin sensitivity. Lack of the α2δ-1 subunit reduces the Ca2+ currents through all HVCC isoforms expressed in β-cells equally in male and female mice. The reduced Ca2+ influx alters the kinetics and amplitude of the global Ca2+ response to glucose in pancreatic islets and significantly reduces insulin release in both sexes. The progression of diabetes in males is aggravated by a selective loss of β-cell mass, while a stronger basal insulin release alleviates the diabetes symptoms in most α2δ-1-/- female mice. Together, these findings demonstrate that the loss of the Ca2+ channel α2δ-1 subunit function increases the susceptibility for developing diabetes in a sex-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://purl.org/dc/terms/identifier | "doi:10.2337/db16-0336"xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://purl.uniprot.org/core/author | "Schwartz A."xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://purl.uniprot.org/core/author | "Hofer H."xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://purl.uniprot.org/core/author | "Flucher B.E."xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://purl.uniprot.org/core/author | "Obermair G.J."xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://purl.uniprot.org/core/author | "Striessnig J."xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://purl.uniprot.org/core/author | "Tuluc P."xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://purl.uniprot.org/core/author | "Flucher S.M."xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://purl.uniprot.org/core/author | "Renstrom E."xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://purl.uniprot.org/core/author | "Drach M."xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://purl.uniprot.org/core/author | "Mastrolia V."xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28115397 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://purl.uniprot.org/core/pages | "897-907"xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://purl.uniprot.org/core/title | "Loss of alphapisub>2pi/sub>delta-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes."xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://purl.uniprot.org/core/volume | "66"xsd:string |
| http://purl.uniprot.org/citations/28115397 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28115397 |
| http://purl.uniprot.org/citations/28115397 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28115397 |
| http://purl.uniprot.org/uniprot/O08532#attribution-BE719BADEFA7233B081A38700271ED4C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28115397 |
| http://purl.uniprot.org/uniprot/#_A0A411ACY8-mappedCitation-28115397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28115397 |
| http://purl.uniprot.org/uniprot/#_E9Q1X8-mappedCitation-28115397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28115397 |
| http://purl.uniprot.org/uniprot/#_O08532-mappedCitation-28115397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28115397 |
| http://purl.uniprot.org/uniprot/#_Q14BH8-mappedCitation-28115397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28115397 |