| http://purl.uniprot.org/citations/28117447 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28117447 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28117447 | http://www.w3.org/2000/01/rdf-schema#comment | "Integrins are adhesion receptors that transmit force across the plasma membrane between extracellular ligands and the actin cytoskeleton. In activation of the transforming growth factor-β1 precursor (pro-TGF-β1), integrins bind to the prodomain, apply force, and release the TGF-β growth factor. However, we know little about how integrins bind macromolecular ligands in the extracellular matrix or transmit force to them. Here we show how integrin αVβ6 binds pro-TGF-β1 in an orientation biologically relevant for force-dependent release of TGF-β from latency. The conformation of the prodomain integrin-binding motif differs in the presence and absence of integrin binding; differences extend well outside the interface and illustrate how integrins can remodel extracellular matrix. Remodelled residues outside the interface stabilize the integrin-bound conformation, adopt a conformation similar to earlier-evolving family members, and show how macromolecular components outside the binding motif contribute to integrin recognition. Regions in and outside the highly interdigitated interface stabilize a specific integrin/pro-TGF-β orientation that defines the pathway through these macromolecules which actin-cytoskeleton-generated tensile force takes when applied through the integrin β-subunit. Simulations of force-dependent activation of TGF-β demonstrate evolutionary specializations for force application through the TGF-β prodomain and through the β- and not α-subunit of the integrin."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature21035"xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature21035"xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Dong X."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Dong X."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Lu C."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Lu C."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Zhao B."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Zhao B."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Springer T.A."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Springer T.A."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Koksal A.C."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Koksal A.C."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Engen J.R."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Engen J.R."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Iacob R.E."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/author | "Iacob R.E."xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/28117447 | http://purl.uniprot.org/core/name | "Nature"xsd:string |