| http://purl.uniprot.org/citations/28122957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28122957 | http://www.w3.org/2000/01/rdf-schema#comment | "Glycolytic enzymes are known to play pivotal roles in cancer cell survival, yet their molecular mechanisms remain poorly understood. Phosphoglycerate mutase 1 (PGAM1) is an important glycolytic enzyme that coordinates glycolysis, pentose phosphate pathway, and serine biosynthesis in cancer cells. Herein, we report that PGAM1 is required for homologous recombination (HR) repair of DNA double-strand breaks (DSBs) caused by DNA-damaging agents. Mechanistically, PGAM1 facilitates DSB end resection by regulating the stability of CTBP-interacting protein (CtIP). Knockdown of PGAM1 in cancer cells accelerates CtIP degradation through deprivation of the intracellular deoxyribonucleotide triphosphate pool and associated activation of the p53/p73 pathway. Enzymatic inhibition of PGAM1 decreases CtIP protein levels, impairs HR repair, and hence sensitizes BRCA1/2-proficient breast cancer to poly(ADP-ribose) polymerase (PARP) inhibitors. Together, this study identifies a metabolically dependent function of PGAM1 in promoting HR repair and reveals a potential therapeutic opportunity for PGAM1 inhibitors in combination with PARP inhibitors."xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201607008"xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/author | "Ding J."xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/author | "Lv H."xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/author | "Sun W."xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/author | "Tan M."xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/author | "Xie Z."xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/author | "Zhong J."xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/author | "Qu J."xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/author | "Zhu M."xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/author | "Huang M."xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/author | "Jin N."xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/author | "Geng M."xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/author | "Lin S.H."xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/pages | "409-424"xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/title | "Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells."xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://purl.uniprot.org/core/volume | "216"xsd:string |
| http://purl.uniprot.org/citations/28122957 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28122957 |
| http://purl.uniprot.org/citations/28122957 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28122957 |
| http://purl.uniprot.org/uniprot/#_B4DKL5-mappedCitation-28122957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28122957 |
| http://purl.uniprot.org/uniprot/#_B4DMJ7-mappedCitation-28122957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28122957 |