| http://purl.uniprot.org/citations/28126738 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28126738 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28126738 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously characterised the histone lysine methyltransferase properties of PRDM9, a member of the PRDM family of putative transcriptional regulators. PRDM9 displays broad substrate recognition and methylates a range of histone substrates, including octamers, core histone proteins, and peptides. In the present study, we show that PRDM9 performs intramolecular automethylation on multiple lysine residues localised to a lysine-rich region on the post-SET (suppressor of variegation 3-9, enhancer of zeste and trithorax) domain. PRDM9 automethylation is abolished by a single active-site mutation, C321P, also known to disrupt interactions with S-adenosylmethionine. We have taken an initial step towards tool compound generation through rational design of a substrate-mimic, peptidic inhibitor of PRDM9 automethylation. The discovery of automethylation in PRDM9 adds a new dimension to our understanding of PRDM9 enzymology."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.org/dc/terms/identifier | "doi:10.1042/bcj20161067"xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.org/dc/terms/identifier | "doi:10.1042/bcj20161067"xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Hill J."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Hill J."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Li R."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Li R."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Peng J."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Peng J."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Joy J."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Joy J."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Guccione E."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Guccione E."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Wee J.L."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Wee J.L."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Chew S.Y."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Chew S.Y."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Koh-Stenta X."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Koh-Stenta X."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Kwek P.Z."xsd:string |
| http://purl.uniprot.org/citations/28126738 | http://purl.uniprot.org/core/author | "Kwek P.Z."xsd:string |