| http://purl.uniprot.org/citations/28128321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28128321 | http://www.w3.org/2000/01/rdf-schema#comment | "Rhythm generating neurons are thought to be ipsilaterally-projecting excitatory neurons in the thoracolumbar mammalian spinal cord. Recently, a subset of Shox2 interneurons (Shox2 non-V2a INs) was found to fulfill these criteria and make up a fraction of the rhythm-generating population. Here we use Hb9::Cre mice to genetically manipulate Hb9::Cre-derived excitatory interneurons (INs) in order to determine the role of these INs in rhythm generation. We demonstrate that this line captures a consistent population of spinal INs which is mixed with respect to neurotransmitter phenotype and progenitor domain, but does not overlap with the Shox2 non-V2a population. We also show that Hb9::Cre-derived INs include the comparatively small medial population of INs which continues to express Hb9 postnatally. When excitatory neurotransmission is selectively blocked by deleting Vglut2 from Hb9::Cre-derived INs, there is no difference in left-right and/or flexor-extensor phasing between these cords and controls, suggesting that excitatory Hb9::Cre-derived INs do not affect pattern generation. In contrast, the frequencies of locomotor activity are significantly lower in cords from Hb9::Cre-Vglut2Δ/Δ mice than in cords from controls. Collectively, our findings indicate that excitatory Hb9::Cre-derived INs constitute a distinct population of neurons that participates in the rhythm generating kernel for spinal locomotion."xsd:string |
| http://purl.uniprot.org/citations/28128321 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep41369"xsd:string |
| http://purl.uniprot.org/citations/28128321 | http://purl.uniprot.org/core/author | "Kiehn O."xsd:string |
| http://purl.uniprot.org/citations/28128321 | http://purl.uniprot.org/core/author | "Borgius L."xsd:string |
| http://purl.uniprot.org/citations/28128321 | http://purl.uniprot.org/core/author | "Dougherty K.J."xsd:string |
| http://purl.uniprot.org/citations/28128321 | http://purl.uniprot.org/core/author | "Caldeira V."xsd:string |
| http://purl.uniprot.org/citations/28128321 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28128321 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28128321 | http://purl.uniprot.org/core/pages | "41369"xsd:string |
| http://purl.uniprot.org/citations/28128321 | http://purl.uniprot.org/core/title | "Spinal Hb9::Cre-derived excitatory interneurons contribute to rhythm generation in the mouse."xsd:string |
| http://purl.uniprot.org/citations/28128321 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28128321 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28128321 |
| http://purl.uniprot.org/citations/28128321 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28128321 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWN6-mappedCitation-28128321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28128321 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0A6-mappedCitation-28128321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28128321 |
| http://purl.uniprot.org/uniprot/#_A0A140LHC9-mappedCitation-28128321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28128321 |
| http://purl.uniprot.org/uniprot/#_D3Z1L8-mappedCitation-28128321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28128321 |
| http://purl.uniprot.org/uniprot/#_D3Z5S3-mappedCitation-28128321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28128321 |
| http://purl.uniprot.org/uniprot/#_P61372-mappedCitation-28128321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28128321 |
| http://purl.uniprot.org/uniprot/#_A0A140LHI9-mappedCitation-28128321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28128321 |
| http://purl.uniprot.org/uniprot/#_A0A140T8S9-mappedCitation-28128321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28128321 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPD4-mappedCitation-28128321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28128321 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPY2-mappedCitation-28128321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28128321 |
| http://purl.uniprot.org/uniprot/#_B2RXV9-mappedCitation-28128321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28128321 |