| http://purl.uniprot.org/citations/28130403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28130403 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulatory T cell (T reg cell) T cell receptor (TCR) repertoire is highly diverse and skewed toward recognition of self-antigens. TCR expression by T reg cells is continuously required for maintenance of immune tolerance and for a major part of their characteristic gene expression signature; however, it remains unknown to what degree diverse TCR-mediated interactions with cognate self-antigens are required for these processes. In this study, by experimentally switching the T reg cell TCR repertoire to a single T reg cell TCR, we demonstrate that T reg cell function and gene expression can be partially uncoupled from TCR diversity. An induced switch of the T reg cell TCR repertoire to a random repertoire also preserved, albeit to a limited degree, the ability to suppress lymphadenopathy and T helper cell type 2 activation. At the same time, these perturbations of the T reg cell TCR repertoire led to marked immune cell activation, tissue inflammation, and an ultimately severe autoimmunity, indicating the importance of diversity and specificity for optimal T reg cell function."xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20161318"xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/author | "Treuting P.M."xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/author | "Rudensky A.Y."xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/author | "Schmidt-Supprian M."xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/author | "Germain R.N."xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/author | "Moltedo B."xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/author | "Hemmers S."xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/author | "Levine A.G."xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/author | "Schizas M."xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/author | "Baptista A.P."xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/author | "Faire M.B."xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/author | "Konopacki C."xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/pages | "609-622"xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/title | "Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity."xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://purl.uniprot.org/core/volume | "214"xsd:string |
| http://purl.uniprot.org/citations/28130403 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28130403 |
| http://purl.uniprot.org/citations/28130403 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28130403 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC35-mappedCitation-28130403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28130403 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC46-mappedCitation-28130403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28130403 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EI60-mappedCitation-28130403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28130403 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4L2R0-mappedCitation-28130403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28130403 |