http://purl.uniprot.org/citations/28131168 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/28131168 | http://www.w3.org/2000/01/rdf-schema#comment | "IntroductionFrontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD) are neurodegenerative diseases that share common genetic risk factors. A recent genome-wide association study has linked risk of FTD with polymorphisms in the HLA-DRA/HLA-DRB5 gene (rs9268877, rs9268856), BTNL2 gene (rs1980493), and RAB38/CTSC gene (rs302668).MethodsWe used the SNPscan™ Kit to genotype these variants in 400 Chinese patients with sporadic ALS, 554 with sporadic PD and 634 healthy controls.ResultsThe AA genotype at rs9268856 increased risk of ALS (P=0.005). Mean survival time was significantly shorter in patients with the AA genotype (24.8±16.2months) than in patients with other genotypes (36.9±19.9months; P<0.001). Kaplan-Meier curves and Cox analysis indicated significantly lower survival probability for patients carrying the AA genotype (P<0.001).ConclusionOur results suggest that the AA genotype at rs9268856 is an independent risk factor and prognostic factor for ALS in Han Chinese from southwest China."xsd:string |
http://purl.uniprot.org/citations/28131168 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jns.2016.12.055"xsd:string |
http://purl.uniprot.org/citations/28131168 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
http://purl.uniprot.org/citations/28131168 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
http://purl.uniprot.org/citations/28131168 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
http://purl.uniprot.org/citations/28131168 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
http://purl.uniprot.org/citations/28131168 | http://purl.uniprot.org/core/author | "Zheng J."xsd:string |
http://purl.uniprot.org/citations/28131168 | http://purl.uniprot.org/core/author | "Tian S."xsd:string |
http://purl.uniprot.org/citations/28131168 | http://purl.uniprot.org/core/author | "An R."xsd:string |
http://purl.uniprot.org/citations/28131168 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
http://purl.uniprot.org/citations/28131168 | http://purl.uniprot.org/core/name | "J Neurol Sci"xsd:string |
http://purl.uniprot.org/citations/28131168 | http://purl.uniprot.org/core/pages | "124-128"xsd:string |
http://purl.uniprot.org/citations/28131168 | http://purl.uniprot.org/core/title | "HLA-DRA/HLA-DRB5 polymorphism affects risk of sporadic ALS and survival in a southwest Chinese cohort."xsd:string |
http://purl.uniprot.org/citations/28131168 | http://purl.uniprot.org/core/volume | "373"xsd:string |
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