Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/28131910http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28131910http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To evaluate the association between polymorphisms in DLX1, DLX2, MMP13, TIMP1 and TIMP2 genes with dental fluorosis (DF) phenotype.

Design

Four hundred and eighty one subjects (108 with DF and 373 DF free) from 6 to 18 years of age were recruited. This population lived in Rio de Janeiro, a city with fluoridation of public water supplies. DF was assessed using the Deańs index modified. Only erupted permanent teeth were assessed. Genetic polymorphisms in DLX1, DLX2, MMP13, TIMP1 and TIMP2 were analyzed by real-time PCR from genomic DNA. Association between DF, genotype, and allele distribution were evaluated using chi-square and logistic regression analyses with an alpha level of 5%.

Results

DF was more prevalent in Afro-descendants than in Caucasians (p=0.08; OR=1.83; CI 95%=1.18-2.82). Logistic regression analysis adjusted by the ethnicity demonstrated a statistical difference for TIMP1 genotype (p=0.033; OR=2.93, 95%CI, 1.09-7.90). When only the severer cases of DF were analyzed, polymorphisms in DLX1 and DLX2 were associated with DF (p<0.05).

Conclusion

Our results provided evidence that polymorphisms in TIMP1, DLX1 and DLX2 genes may be associated with DF phenotypes."xsd:string
http://purl.uniprot.org/citations/28131910http://purl.org/dc/terms/identifier"doi:10.1016/j.archoralbio.2017.01.009"xsd:string
http://purl.uniprot.org/citations/28131910http://purl.uniprot.org/core/author"Costa M.C."xsd:string
http://purl.uniprot.org/citations/28131910http://purl.uniprot.org/core/author"Silva R.A."xsd:string
http://purl.uniprot.org/citations/28131910http://purl.uniprot.org/core/author"Oliveira D.S."xsd:string
http://purl.uniprot.org/citations/28131910http://purl.uniprot.org/core/author"Kuchler E.C."xsd:string
http://purl.uniprot.org/citations/28131910http://purl.uniprot.org/core/author"Tannure P.N."xsd:string
http://purl.uniprot.org/citations/28131910http://purl.uniprot.org/core/author"Nelson-Filho P."xsd:string
http://purl.uniprot.org/citations/28131910http://purl.uniprot.org/core/author"Antunes L.A."xsd:string
http://purl.uniprot.org/citations/28131910http://purl.uniprot.org/core/author"Antunes L.S."xsd:string
http://purl.uniprot.org/citations/28131910http://purl.uniprot.org/core/author"Calasans Maia M.D."xsd:string
http://purl.uniprot.org/citations/28131910http://purl.uniprot.org/core/author"Charone S."xsd:string
http://purl.uniprot.org/citations/28131910http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28131910http://purl.uniprot.org/core/name"Arch Oral Biol"xsd:string
http://purl.uniprot.org/citations/28131910http://purl.uniprot.org/core/pages"66-69"xsd:string
http://purl.uniprot.org/citations/28131910http://purl.uniprot.org/core/title"Polymorphisms in genes involved in enamel development are associated with dental fluorosis."xsd:string
http://purl.uniprot.org/citations/28131910http://purl.uniprot.org/core/volume"76"xsd:string
http://purl.uniprot.org/citations/28131910http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/28131910
http://purl.uniprot.org/citations/28131910http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/28131910
http://purl.uniprot.org/uniprot/#_B3KQF4-mappedCitation-28131910http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28131910
http://purl.uniprot.org/uniprot/#_B4DJK3-mappedCitation-28131910http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28131910
http://purl.uniprot.org/uniprot/#_Q53SU3-mappedCitation-28131910http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28131910
http://purl.uniprot.org/uniprot/#_P01033-mappedCitation-28131910http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28131910
http://purl.uniprot.org/uniprot/#_Q6FGX5-mappedCitation-28131910http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28131910
▶