http://purl.uniprot.org/citations/28134253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/28134253 | http://www.w3.org/2000/01/rdf-schema#comment | "The Structural Maintenance of Chromosomes (SMC) complexes: cohesin, condensin and Smc5/6 are involved in the organization of higher-order chromosome structure-which is essential for accurate chromosome duplication and segregation. Each complex is scaffolded by a specific SMC protein dimer (heterodimer in eukaryotes) held together via their hinge domains. Here we show that the Smc5/6-hinge, like those of cohesin and condensin, also forms a toroidal structure but with distinctive subunit interfaces absent from the other SMC complexes; an unusual 'molecular latch' and a functional 'hub'. Defined mutations in these interfaces cause severe phenotypic effects with sensitivity to DNA-damaging agents in fission yeast and reduced viability in human cells. We show that the Smc5/6-hinge complex binds preferentially to ssDNA and that this interaction is affected by both 'latch' and 'hub' mutations, suggesting a key role for these unique features in controlling DNA association by the Smc5/6 complex."xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms14011"xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/author | "Oliver A.W."xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/author | "Pearl L.H."xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/author | "Murray J.M."xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/author | "Polo L.M."xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/author | "Smith M.A."xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/author | "Lehmann A.R."xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/author | "Alt A."xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/author | "Welte T."xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/author | "McGregor G.A."xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/author | "Wells O.S."xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/author | "Dang H.Q."xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/pages | "14011"xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/title | "Specialized interfaces of Smc5/6 control hinge stability and DNA association."xsd:string |
http://purl.uniprot.org/citations/28134253 | http://purl.uniprot.org/core/volume | "8"xsd:string |
http://purl.uniprot.org/citations/28134253 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28134253 |
http://purl.uniprot.org/citations/28134253 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28134253 |
http://purl.uniprot.org/uniprot/O13710#attribution-FD8B784847F245966B6C028C7F1EFE48 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28134253 |
http://purl.uniprot.org/uniprot/P53692#attribution-FD8B784847F245966B6C028C7F1EFE48 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28134253 |
http://purl.uniprot.org/uniprot/#_A0A2S1ZR79-mappedCitation-28134253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28134253 |
http://purl.uniprot.org/uniprot/#_A0A2S1ZR87-mappedCitation-28134253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28134253 |