| http://purl.uniprot.org/citations/28135254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28135254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28135254 | http://www.w3.org/2000/01/rdf-schema#comment | "The FcμR receptor for the crystallizable fragment (Fc) of immunoglobulin M (IgM) can function as a cell-surface receptor for secreted IgM on a variety of cell types. We found here that FcμR was also expressed in the trans-Golgi network of developing B cells, where it constrained transport of the IgM-isotype BCR (IgM-BCR) but not of the IgD-isotype BCR (IgD-BCR). In the absence of FcμR, the surface expression of IgM-BCR was increased, which resulted in enhanced tonic BCR signaling. B-cell-specific deficiency in FcμR enhanced the spontaneous differentiation of B-1 cells, which resulted in increased serum concentrations of natural IgM and dysregulated homeostasis of B-2 cells; this caused the spontaneous formation of germinal centers, increased titers of serum autoantibodies and excessive accumulation of B cells. Thus, FcμR serves as a critical regulator of B cell biology by constraining the transport and cell-surface expression of IgM-BCR."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3677"xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3677"xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Nguyen T.T."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Nguyen T.T."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Baumgarth N."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Baumgarth N."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Reth M."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Reth M."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Bevins C.L."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Bevins C.L."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Castillo P.A."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Castillo P.A."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Brust-Mascher I."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Brust-Mascher I."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Imai D.M."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Imai D.M."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Klaesener K."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Klaesener K."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Reardon C."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Reardon C."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Zuern C."xsd:string |
| http://purl.uniprot.org/citations/28135254 | http://purl.uniprot.org/core/author | "Zuern C."xsd:string |