| http://purl.uniprot.org/citations/28137874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28137874 | http://www.w3.org/2000/01/rdf-schema#comment | "Class-switch recombination (CSR) alters the Ig isotype to diversify antibody effector functions. IgD CSR is a rare event, and its regulation is poorly understood. We report that deficiency of 53BP1, a DNA damage-response protein, caused age-dependent overproduction of secreted IgD resulting from increased IgD CSR exclusively within B cells of mucosa-associated lymphoid tissues. IgD overproduction was dependent on activation-induced cytidine deaminase, hematopoietic MyD88 expression, and an intact microbiome, against which circulating IgD, but not IgM, was reactive. IgD CSR occurred via both alternative nonhomologous end-joining and homologous recombination pathways. Microbiota-dependent IgD CSR also was detected in nasal-associated lymphoid tissue of WT mice. These results identify a pathway, present in WT mice and hyperactivated in 53BP1-deficient mice, by which microbiota signal via Toll-like receptors to elicit IgD CSR."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1621258114"xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Tang M."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Hooper L.V."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Zhan X."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Zeng M."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Choi J.H."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Hildebrand S."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Beutler B."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Misawa T."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Murray A.R."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Wang K.W."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Scott L."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Bu C.H."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Moresco E.M."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Behrendt C.L."xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/author | "Zhan X.'"xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/28137874 | http://purl.uniprot.org/core/pages | "E1196-E1204"xsd:string |