| http://purl.uniprot.org/citations/28145888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28145888 | http://www.w3.org/2000/01/rdf-schema#comment | "ADAMTS18 is a novel tumor suppressor and is critical to the pathology of human colorectal cancer. However, the underlying mechanism is not clear. Here we generated an Adamts18-deficient mouse strain as an in vivo model to investigate the role of ADAMTS18 in the pathogenesis of colorectal cancer. In AOM/DSS-induced colitis-associated colorectal cancer, the deficiency of Adamts18 in mice resulted in enhanced tumorigenesis and colon inflammation that could be attributed in part to enhanced nuclear translocation of β-catenin and elevated expression of its downstream target genes, cyclin D1 and c-myc. Moreover, increased p38MAPK and ERK1/2 activities were detected in colon cancer cells from Adamts18-deficient mice. Further studies revealed that ADAMTS18 deficiency reduced intestinal E-cadherin levels in mice, which ultimately led to intestinal barrier dysfunction. These data indicate that Adamts18 deficiency enhances tumorigenesis and intestinal inflammation through elevated Wnt/β-catenin and p38MAPK/ERK1/2 signaling and promotes colon cancer in this mouse model."xsd:string |
| http://purl.uniprot.org/citations/28145888 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.14866"xsd:string |
| http://purl.uniprot.org/citations/28145888 | http://purl.uniprot.org/core/author | "Lu T."xsd:string |
| http://purl.uniprot.org/citations/28145888 | http://purl.uniprot.org/core/author | "Hong T."xsd:string |
| http://purl.uniprot.org/citations/28145888 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/28145888 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/28145888 | http://purl.uniprot.org/core/author | "Zhu R."xsd:string |
| http://purl.uniprot.org/citations/28145888 | http://purl.uniprot.org/core/author | "Dang S."xsd:string |
| http://purl.uniprot.org/citations/28145888 | http://purl.uniprot.org/core/author | "Nie Z."xsd:string |
| http://purl.uniprot.org/citations/28145888 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28145888 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/28145888 | http://purl.uniprot.org/core/pages | "18979-18990"xsd:string |
| http://purl.uniprot.org/citations/28145888 | http://purl.uniprot.org/core/title | "Adamts18 deficiency promotes colon carcinogenesis by enhancing beta-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer."xsd:string |
| http://purl.uniprot.org/citations/28145888 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/28145888 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28145888 |
| http://purl.uniprot.org/citations/28145888 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28145888 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RLA5-mappedCitation-28145888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28145888 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RLE1-mappedCitation-28145888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28145888 |
| http://purl.uniprot.org/uniprot/#_B7ZMV1-mappedCitation-28145888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28145888 |
| http://purl.uniprot.org/uniprot/#_Q4VC17-mappedCitation-28145888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28145888 |
| http://purl.uniprot.org/uniprot/#_Q3TR71-mappedCitation-28145888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28145888 |
| http://purl.uniprot.org/uniprot/#_Q8BV18-mappedCitation-28145888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28145888 |
| http://purl.uniprot.org/uniprot/#_Q8BKA1-mappedCitation-28145888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28145888 |
| http://purl.uniprot.org/uniprot/A0A1D5RLA5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28145888 |