| http://purl.uniprot.org/citations/28150906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28150906 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin-like growth factor binding protein 4 (IGFBP-4) and cyclooxygenase2 (COX-2) are associated with tumor inflammatory microenvironment which is involved in the progression of tumor. However, it is unclear that the roles of IGFBP-4 in lung cancer and the effects of IGFBP-4 on COX-2 expression. In this study, we showed that IGFBP-4 could decrease COX-2 production in lung cancer A549 cells. IGFBP-4 expression was significantly lower but COX-2 expression was higher in lung cancer tissues compared to matched adjacent normal tissues. In addition, IGFBP-4 could inhibit lung cancer cell proliferation, migration and invasion, and suppress the phosphorylation of PI3 K/AKT, ERK, and CREB. These results indicate that IGFBP-4 has potent antitumor effects in non-small cell lung cancer cells."xsd:string |
| http://purl.uniprot.org/citations/28150906 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbin.10732"xsd:string |
| http://purl.uniprot.org/citations/28150906 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/28150906 | http://purl.uniprot.org/core/author | "Sun D."xsd:string |
| http://purl.uniprot.org/citations/28150906 | http://purl.uniprot.org/core/author | "Wei Y."xsd:string |
| http://purl.uniprot.org/citations/28150906 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/28150906 | http://purl.uniprot.org/core/author | "Zheng L."xsd:string |
| http://purl.uniprot.org/citations/28150906 | http://purl.uniprot.org/core/author | "Lv Z."xsd:string |
| http://purl.uniprot.org/citations/28150906 | http://purl.uniprot.org/core/author | "Zeng T."xsd:string |
| http://purl.uniprot.org/citations/28150906 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28150906 | http://purl.uniprot.org/core/name | "Cell Biol Int"xsd:string |
| http://purl.uniprot.org/citations/28150906 | http://purl.uniprot.org/core/pages | "384-391"xsd:string |
| http://purl.uniprot.org/citations/28150906 | http://purl.uniprot.org/core/title | "Insulin-like growth factor binding protein-4 inhibits cell growth, migration and invasion, and downregulates COX-2 expression in A549 lung cancer cells."xsd:string |
| http://purl.uniprot.org/citations/28150906 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/28150906 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28150906 |
| http://purl.uniprot.org/citations/28150906 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28150906 |
| http://purl.uniprot.org/uniprot/#_B4F438-mappedCitation-28150906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28150906 |
| http://purl.uniprot.org/uniprot/#_P22692-mappedCitation-28150906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28150906 |
| http://purl.uniprot.org/uniprot/P22692 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28150906 |
| http://purl.uniprot.org/uniprot/B4F438 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28150906 |