| http://purl.uniprot.org/citations/28154132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28154132 | http://www.w3.org/2000/01/rdf-schema#comment | "Inositol hexakisphosphate kinase 1 (IP6K1), which generates 5-diphosphoinositol pentakisphosphate (5-IP7), physiologically mediates numerous functions. We report that IP6K1 deletion leads to brain malformation and abnormalities of neuronal migration. IP6K1 physiologically associates with α-actinin and localizes to focal adhesions. IP6K1 deletion disrupts α-actinin's intracellular localization and function. The IP6K1 deleted cells display substantial decreases of stress fiber formation and impaired cell migration and spreading. Regulation of α-actinin by IP6K1 requires its kinase activity. Deletion of IP6K1 abolishes α-actinin tyrosine phosphorylation, which is known to be regulated by focal adhesion kinase (FAK). FAK phosphorylation is substantially decreased in IP6K1 deleted cells. 5-IP7, a product of IP6K1, promotes FAK autophosphorylation. Pharmacologic inhibition of IP6K by TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] recapitulates the phenotype of IP6K1 deletion. These findings establish that IP6K1 physiologically regulates neuronal migration by binding to α-actinin and influencing phosphorylation of both FAK and α-actinin through its product 5-IP7."xsd:string |
| http://purl.uniprot.org/citations/28154132 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1700165114"xsd:string |
| http://purl.uniprot.org/citations/28154132 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/28154132 | http://purl.uniprot.org/core/author | "Snyder S.H."xsd:string |
| http://purl.uniprot.org/citations/28154132 | http://purl.uniprot.org/core/author | "Fu C."xsd:string |
| http://purl.uniprot.org/citations/28154132 | http://purl.uniprot.org/core/author | "Cheng W."xsd:string |
| http://purl.uniprot.org/citations/28154132 | http://purl.uniprot.org/core/author | "Snowman A.M."xsd:string |
| http://purl.uniprot.org/citations/28154132 | http://purl.uniprot.org/core/author | "Harraz M.M."xsd:string |
| http://purl.uniprot.org/citations/28154132 | http://purl.uniprot.org/core/author | "Chin A.C."xsd:string |
| http://purl.uniprot.org/citations/28154132 | http://purl.uniprot.org/core/author | "Rojas T."xsd:string |
| http://purl.uniprot.org/citations/28154132 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28154132 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/28154132 | http://purl.uniprot.org/core/pages | "2036-2041"xsd:string |
| http://purl.uniprot.org/citations/28154132 | http://purl.uniprot.org/core/title | "Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via alpha-actinin and focal adhesion kinase."xsd:string |
| http://purl.uniprot.org/citations/28154132 | http://purl.uniprot.org/core/volume | "114"xsd:string |
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