| http://purl.uniprot.org/citations/28154144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28154144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28154144 | http://www.w3.org/2000/01/rdf-schema#comment | "The exact function of human gasdermin-B (GSDMB), which regulates differentiation and growth of epithelial cells, is yet to be elucidated. In human epidermal growth factor receptor 2 (HER2)-positive breast cancer, GSDMB gene amplification and protein overexpression indicate a poor response to HER2-targeted therapy. Genome-wide association studies revealed a correlation between GSDMB SNPs and an increased susceptibility to Crohn's disease, ulcerative colitis, and asthma. The N- and C-terminal domains of all gasdermins possess lipid-binding and regulatory activities, respectively. Inflammatory caspases cleave gasdermin-D in the interdomain linker but not GSDMB. The cleaved N-terminal domain binds phosphoinositides and cardiolipin, forms membrane-disrupting pores, and executes pyroptosis. We show that both full-length GSDMB and the N-terminal domain bind to nitrocellulose membranes immobilized with phosphoinositides or sulfatide, but not with cardiolipin. In addition, the GSDMB N-terminal domain binds liposomes containing sulfatide. The crystal structure of the GSDMB C-terminal domain reveals the structural impact of the amino acids encoded by SNPs that are linked to asthma and inflammatory bowel disease (IBD). A loop that carries the polymorphism amino acids corresponding to healthy individuals (Gly299:Pro306) exhibits high conformational flexibility, whereas the loop carrying amino acids found in individuals with increased disease risk (Arg299:Ser306) exhibits a well-defined conformation and higher positive surface charge. Apoptotic executioner caspase-3, -6, and -7, but not the inflammatory caspases, cleave GSDMB at 88DNVD91 within the N-terminal domain. Selective sulfatide binding may indicate possible function for GSDMB in the cellular sulfatide transport."xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1616783114"xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1616783114"xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/author | "Herzberg O."xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/author | "Herzberg O."xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/author | "Kulakova L."xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/author | "Kulakova L."xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/author | "Chao K.L."xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/author | "Chao K.L."xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/pages | "E1128-E1137"xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/pages | "E1128-E1137"xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/title | "Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein."xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/title | "Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein."xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/28154144 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28154144 |
| http://purl.uniprot.org/citations/28154144 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28154144 |
| http://purl.uniprot.org/citations/28154144 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28154144 |
| http://purl.uniprot.org/citations/28154144 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28154144 |