| http://purl.uniprot.org/citations/28155233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28155233 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor receptor-associated factor 1 (TRAF1) is a multifunctional adaptor protein involved in important processes of cellular signaling, including innate immunity and apoptosis. TRAF family member-associated NF-kappaB activator (TANK) has been identified as a competitive intracellular inhibitor of TRAF2 function. Although TRAF recognition by various receptors has been studied extensively in the field of TRAF-mediated biology, molecular and functional details of TANK recognition and interaction with TRAF1 have not been studied. In this study, we report the crystal structure of the TRAF1/TANK peptide complex. Quantitative interaction experiments showed that TANK peptide interacts with both TRAF1 and TRAF2 with similar affinity in a micromolar range. Our structural study also reveals that TANK binds TRAF1 using a minor minimal consensus motif for TRAF binding, Px(Q/E)xT.DatabaseCoordinate and structural factor were deposited in the Protein Data Bank under PDB ID code 5H10."xsd:string |
| http://purl.uniprot.org/citations/28155233 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.12584"xsd:string |
| http://purl.uniprot.org/citations/28155233 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/28155233 | http://purl.uniprot.org/core/author | "Kim C.M."xsd:string |
| http://purl.uniprot.org/citations/28155233 | http://purl.uniprot.org/core/author | "Son Y.J."xsd:string |
| http://purl.uniprot.org/citations/28155233 | http://purl.uniprot.org/core/author | "Choi J.H."xsd:string |
| http://purl.uniprot.org/citations/28155233 | http://purl.uniprot.org/core/author | "Park H.H."xsd:string |
| http://purl.uniprot.org/citations/28155233 | http://purl.uniprot.org/core/author | "Jeong J.H."xsd:string |
| http://purl.uniprot.org/citations/28155233 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28155233 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/28155233 | http://purl.uniprot.org/core/pages | "810-821"xsd:string |
| http://purl.uniprot.org/citations/28155233 | http://purl.uniprot.org/core/title | "Molecular basis for TANK recognition by TRAF1 revealed by the crystal structure of TRAF1/TANK complex."xsd:string |
| http://purl.uniprot.org/citations/28155233 | http://purl.uniprot.org/core/volume | "591"xsd:string |
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