| http://purl.uniprot.org/citations/28165510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28165510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28165510 | http://www.w3.org/2000/01/rdf-schema#comment | "Type I interferons (IFNs) are multifunctional cytokines that regulate immune responses and cellular functions but also can have detrimental effects on human health. A tight regulatory network therefore controls IFN signaling, which in turn may interfere with medical interventions. The JAK-STAT signaling pathway transmits the IFN extracellular signal to the nucleus, thus resulting in alterations in gene expression. STAT2 is a well-known essential and specific positive effector of type I IFN signaling. Here, we report that STAT2 is also a previously unrecognized, crucial component of the USP18-mediated negative-feedback control in both human and mouse cells. We found that STAT2 recruits USP18 to the type I IFN receptor subunit IFNAR2 via its constitutive membrane-distal STAT2-binding site. This mechanistic coupling of effector and negative-feedback functions of STAT2 may provide novel strategies for treatment of IFN-signaling-related human diseases."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.3378"xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.3378"xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Piehler J."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Piehler J."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Fan J.B."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Fan J.B."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Yan M."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Yan M."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Heinisch J.J."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Heinisch J.J."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Colland F."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Colland F."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Zhang D.E."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Zhang D.E."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Miyauchi S."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Miyauchi S."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Pellegrini S."xsd:string |
| http://purl.uniprot.org/citations/28165510 | http://purl.uniprot.org/core/author | "Pellegrini S."xsd:string |