| http://purl.uniprot.org/citations/28167776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28167776 | http://www.w3.org/2000/01/rdf-schema#comment | "TGF-β is an anti-inflammatory cytokine whose signaling is negatively controlled by Smad7. Previously, we established a role for Smad7 in the generation of autoreactive T cells; however, the function of Smad7 in dendritic cells (DCs) remains elusive. Here, we demonstrate that DC-specific Smad7 deficiency resulted in elevated expression of the transcription factors Batf3 and IRF8, leading to increased frequencies of CD8+CD103+ DCs in the spleen. Furthermore, Smad7-deficient DCs expressed higher levels of indoleamine 2,3-dioxygenase (IDO), an enzyme associated with tolerance induction. Mice devoid of Smad7 specifically in DCs are resistant to the development of experimental autoimmune encephalomyelitis (EAE) as a result of an increase of protective regulatory T cells (Tregs) and reduction of encephalitogenic effector T cells in the central nervous system. In agreement, inhibition of IDO activity or depletion of Tregs restored disease susceptibility. Intriguingly, when Smad7-deficient DCs also lacked the IFN-γ receptor, the mice regained susceptibility to EAE, demonstrating that IFN-γ signaling in DCs mediates their tolerogenic function. Our data indicate that Smad7 expression governs splenic DC subset differentiation and is critical for the promotion of their efficient function in immunity."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1615065114"xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/author | "Mufazalov I.A."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/author | "Waisman A."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/author | "Clausen B.E."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/author | "Muller W."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/author | "Reizis B."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/author | "Kurschus F.C."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/author | "Prinz M."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/author | "Regen T."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/author | "Yogev N."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/author | "Lukas D."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/author | "Kleiter I."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/author | "Kel J.M."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/author | "Wanke F."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/pages | "E1480-E1489"xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/title | "TGF-beta inhibitor Smad7 regulates dendritic cell-induced autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/28167776 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28167776 |
| http://purl.uniprot.org/citations/28167776 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28167776 |
| http://purl.uniprot.org/uniprot/#_B2RPW6-mappedCitation-28167776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28167776 |