| http://purl.uniprot.org/citations/28171748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28171748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28171748 | http://www.w3.org/2000/01/rdf-schema#comment | "Planarian flatworms maintain their body plan in the face of constant internal turnover and can regenerate from arbitrary tissue fragments. Both phenomena require self-maintaining and self-organizing patterning mechanisms, the molecular mechanisms of which remain poorly understood. We show that a morphogenic gradient of canonical Wnt signaling patterns gene expression along the planarian anteroposterior (A/P) axis. Our results demonstrate that gradient formation likely occurs autonomously in the tail and that an autoregulatory module of Wnt-mediated Wnt expression both shapes the gradient at steady state and governs its re-establishment during regeneration. Functional antagonism between the tail Wnt gradient and an unknown head patterning system further determines the spatial proportions of the planarian A/P axis and mediates mutually exclusive molecular fate choices during regeneration. Overall, our results suggest that the planarian A/P axis is patterned by self-organizing patterning systems deployed from either end that are functionally coupled by mutual antagonism."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2016.12.024"xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Friedrich B."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Friedrich B."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Liu S.Y."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Liu S.Y."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Werner S."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Werner S."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Rink J.C."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Rink J.C."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Bayersdorf R."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Bayersdorf R."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Cleland J.P."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Cleland J.P."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Julicher F."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Julicher F."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Stuckemann T."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Stuckemann T."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Thi-Kim Vu H."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/author | "Thi-Kim Vu H."xsd:string |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28171748 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |