| http://purl.uniprot.org/citations/28173122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28173122 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA damage and repair is a critical domain of many neurodegenerative diseases. In this study, we focused on RpA1, a candidate key molecule in polyQ disease pathologies, and tested the therapeutic effect of adeno-associated virus (AAV) vector expressing RpA1 on mutant Ataxin-1 knock-in (Atxn1-KI) mice. We found significant effects on motor functions, normalized DNA damage markers (γH2AX and 53BP1), and improved Purkinje cell morphology; effects that lasted for 50 weeks following AAV-RpA1 infection. In addition, we confirmed that AAV-RpA1 indirectly recovered multiple cellular functions such as RNA splicing, transcription and cell cycle as well as abnormal morphology of dendrite and dendritic spine of Purkinje cells in Atxn1-KI mice. All these results suggested a possibility of gene therapy with RpA1 for SCA1."xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddw272"xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/author | "Fujita K."xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/author | "Homma H."xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/author | "Kondo K."xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/author | "Tanaka T."xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/author | "Tamura T."xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/author | "Mao Y."xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/author | "Tagawa K."xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/author | "Okazawa H."xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/author | "Sudo T."xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/author | "Watase K."xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/author | "Muramatsu S.I."xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/author | "Taniguchi J.B."xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/pages | "4432-4447"xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/title | "RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair."xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/28173122 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28173122 |
| http://purl.uniprot.org/citations/28173122 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28173122 |
| http://purl.uniprot.org/uniprot/#_P54254-mappedCitation-28173122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28173122 |
| http://purl.uniprot.org/uniprot/#_J3QPR1-mappedCitation-28173122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28173122 |