| http://purl.uniprot.org/citations/28190771 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28190771 | http://www.w3.org/2000/01/rdf-schema#comment | "Low-grade systemic inflammation associated to obesity leads to cardiovascular complications, caused partly by infiltration of adipose and vascular tissue by effector T cells. The signals leading to T cell differentiation and tissue infiltration during obesity are poorly understood. We tested whether saturated fatty acid-induced metabolic stress affects differentiation and trafficking patterns of CD4+ T cells. Memory CD4+ T cells primed in high-fat diet-fed donors preferentially migrated to non-lymphoid, inflammatory sites, independent of the metabolic status of the hosts. This was due to biased CD4+ T cell differentiation into CD44hi-CCR7lo-CD62Llo-CXCR3+-LFA1+ effector memory-like T cells upon priming in high-fat diet-fed animals. Similar phenotype was observed in obese subjects in a cohort of free-living people. This developmental bias was independent of any crosstalk between CD4+ T cells and dendritic cells and was mediated via direct exposure of CD4+ T cells to palmitate, leading to increased activation of a PI3K p110δ-Akt-dependent pathway upon priming."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2017.01.008"xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Fu H."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Smith J."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Mauro C."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Caruso D."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Mitro N."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Cucchi D."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Catapano A.L."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Norata G.D."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Marelli-Berg F.M."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Okkenhaug K."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Longhi M.P."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Coe D."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Ammirati E."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Cermenati G."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Baragetti A."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/author | "Bonacina F."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/pages | "593-609"xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/title | "Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4pisup>+pi/sup> T Cell Differentiation via PI3K p110delta-Akt-Mediated Signals."xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/28190771 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28190771 |