| http://purl.uniprot.org/citations/28191643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28191643 | http://www.w3.org/2000/01/rdf-schema#comment | "Th17 cells are often associated with autoimmunity and been shown to be increased in CD11b-/- mice. Here, we examined the role of CD11b in murine collagen-induced arthritis (CIA). C57BL/6 and CD11b-/- resistant mice were immunized with type II collagen. CD11b-/- mice developed arthritis with early onset, high incidence, and sustained severity compared with C57BL/6 mice. We observed a marked leukocyte infiltration, and histological examinations of the arthritic paws from CD11b-/- mice revealed that the cartilage was destroyed in association with strong lymphocytic infiltration. The CD11b deficiency led to enhanced Th17-cell differentiation. CD11b-/- dendritic cells (DCs) induced much stronger IL-6 production and hence Th17-cell differentiation than wild-type DCs. Treatment of CD11b-/- mice after establishment of the Treg/Th17 balance with an anti-IL-6 receptor mAb significantly suppressed the induction of Th17 cells and reduced arthritis severity. Finally, the severe phenotype of arthritis in CD11b-/- mice was rescued by adoptive transfer of CD11b+ DCs. Taken together, our results indicate that the resistance to CIA in C57BL/6 mice is regulated by CD11b via suppression of IL-6 production leading to reduced Th17-cell differentiation. Therefore, CD11b may represent a susceptibility factor for autoimmunity and could be a target for future therapy."xsd:string |
| http://purl.uniprot.org/citations/28191643 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201646565"xsd:string |
| http://purl.uniprot.org/citations/28191643 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/28191643 | http://purl.uniprot.org/core/author | "Acha-Orbea H."xsd:string |
| http://purl.uniprot.org/citations/28191643 | http://purl.uniprot.org/core/author | "Busso N."xsd:string |
| http://purl.uniprot.org/citations/28191643 | http://purl.uniprot.org/core/author | "Ehirchiou D."xsd:string |
| http://purl.uniprot.org/citations/28191643 | http://purl.uniprot.org/core/author | "Chobaz V."xsd:string |
| http://purl.uniprot.org/citations/28191643 | http://purl.uniprot.org/core/author | "Ghassem-Zadeh S."xsd:string |
| http://purl.uniprot.org/citations/28191643 | http://purl.uniprot.org/core/author | "Pigni M."xsd:string |
| http://purl.uniprot.org/citations/28191643 | http://purl.uniprot.org/core/author | "Stevanin M."xsd:string |
| http://purl.uniprot.org/citations/28191643 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28191643 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/28191643 | http://purl.uniprot.org/core/pages | "637-645"xsd:string |
| http://purl.uniprot.org/citations/28191643 | http://purl.uniprot.org/core/title | "CD11b regulates the Treg/Th17 balance in murine arthritis via IL-6."xsd:string |
| http://purl.uniprot.org/citations/28191643 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/28191643 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28191643 |
| http://purl.uniprot.org/citations/28191643 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28191643 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-28191643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28191643 |
| http://purl.uniprot.org/uniprot/#_Q0PMN1-mappedCitation-28191643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28191643 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFG1-mappedCitation-28191643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28191643 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFT1-mappedCitation-28191643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28191643 |
| http://purl.uniprot.org/uniprot/#_A2RTD1-mappedCitation-28191643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28191643 |
| http://purl.uniprot.org/uniprot/#_P08505-mappedCitation-28191643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28191643 |
| http://purl.uniprot.org/uniprot/#_Q3U8J8-mappedCitation-28191643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28191643 |