| http://purl.uniprot.org/citations/28198361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28198361 | http://www.w3.org/2000/01/rdf-schema#comment | "Snail1, a key transcription factor of epithelial-mesenchymal transition (EMT), is subjected to ubiquitination and degradation, but the mechanism by which Snail1 is stabilized in tumours remains unclear. We identify Dub3 as a bona fide Snail1 deubiquitinase, which interacts with and stabilizes Snail1. Dub3 is overexpressed in breast cancer; knockdown of Dub3 resulted in Snail1 destabilization, suppressed EMT and decreased tumour cell migration, invasion, and metastasis. These effects are rescued by ectopic Snail1 expression. IL-6 also stabilizes Snail1 by inducing Dub3 expression, the specific inhibitor WP1130 binds to Dub3 and inhibits the Dub3-mediating Snail1 stabilization in vitro and in vivo. Our study reveals a critical Dub3-Snail1 signalling axis in EMT and metastasis, and provides an effective therapeutic approach against breast cancer."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms14228"xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Jia J."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Lin Y."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Shi Q."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Deng J."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Singh P."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Wang Y.'"xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Dong C."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Chi Y.I."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Tao M."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Zhou B.P."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Evers B.M."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/author | "Napier D."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/pages | "14228"xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/title | "Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation."xsd:string |
| http://purl.uniprot.org/citations/28198361 | http://purl.uniprot.org/core/volume | "8"xsd:string |