| http://purl.uniprot.org/citations/28209511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28209511 | http://www.w3.org/2000/01/rdf-schema#comment | "Heparanase-1/syndecan-1 axis plays critical roles in tumorigenesis and development. The main mechanism includes heparanase-1 (HPA-1) degrades the heparan sulfate chain of syndecan-1 (SDC-1), and the following shedding of heparan sulfate from tumor cell releases and activates SDC-1 sequestered growth factors. However, the significance of Heparanase-1/syndecan-1 axis and its effects on the microenvironment of lymphatic metastasis in hepatocellular carcinogenesis (HCC) procession have not been reported. Herein, we found that HPA-1 could degrade the heparan sulfate on hepatocarcinoma cell surface. Importantly, HPA-1-induced shedding of heparan sulfate chain from SDC-1 facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1/VEGF-C complex into the medium of hepatocarcinoma cell. Further studies indicated that VEGF-C secretion from hepatocarcinoma cell promoted lymphatic endothelial cell growth through activating extracellular signal-regulated kinase (ERK) signaling. Taken together, this study reveals a novel existence of Heparanase-1/syndecan-1 axis in hepatocarcinoma cell and its roles in the cross-talking with the microenvironment of lymphatic metastasis."xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2017.02.060"xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/author | "Hong Y."xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/author | "Jiang L."xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/author | "Lv H."xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/author | "Yu S."xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/author | "Zhang J.'"xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/author | "Ou G."xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/author | "Xia R."xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/author | "Ju W."xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/pages | "432-439"xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/title | "Heparanase-1-induced shedding of heparan sulfate from syndecan-1 in hepatocarcinoma cell facilitates lymphatic endothelial cell proliferation via VEGF-C/ERK pathway."xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://purl.uniprot.org/core/volume | "485"xsd:string |
| http://purl.uniprot.org/citations/28209511 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28209511 |
| http://purl.uniprot.org/citations/28209511 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28209511 |
| http://purl.uniprot.org/uniprot/#_P97953-mappedCitation-28209511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28209511 |
| http://purl.uniprot.org/uniprot/#_Q6YGZ1-mappedCitation-28209511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28209511 |