| http://purl.uniprot.org/citations/28211154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28211154 | http://www.w3.org/2000/01/rdf-schema#comment | "Killer immunoglobulin-like receptors (KIRs) regulate the activation of natural killer cells through their interaction with human leucocyte antigens (HLA). KIR and HLA loci are highly polymorphic, and certain HLA-KIR combinations have been found to protect against viral infections. In this study, we analysed whether the KIR/HLA repertoire may influence the course of hepatitis B virus (HBV) infection. Fifty-seven subjects with chronic hepatitis B (CHB), 44 subjects with resolved HBV infection and 60 healthy uninfected controls (HC) were genotyped for KIR and their HLA ligands. The frequency of the HLA-A-Bw4 ligand group was higher in CHB (58%) than subjects with resolved infection (23%) (crude OR, 4.67; P<.001) and HC (10%) (crude OR, 12.38; P<.001). Similar results were obtained for the HLA-C2 ligand group, more frequent in CHB (84%), than subjects with resolved infection (70%) (crude OR, 2.24; P<.10) and HC (60%) (crude OR, 3.56; P<.01). Conversely, the frequency of KIR2DL3 was lower in CHB (81%) than in subjects with resolved infection (98%) (crude OR, 0.10; P<.05). These results suggest a detrimental role of HLA-A-Bw4 and HLA-C2 groups, which are associated with the development of CHB, and a protective role of KIR2DL3. A stepwise variable selection procedure, based on multiple logistic regression analysis, identified these three predictive variables as the most relevant, featuring high specificity (90.9%) and positive predictive value (87.5%) for the development of CHB. Our results suggest that a combination of KIR/HLA gene/alleles is able to predict the outcome of HBV infection."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.org/dc/terms/identifier | "doi:10.1111/jvh.12698"xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Caruso C."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Di Lorenzo G."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Duro G."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Rizzo S."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Aiello A."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Montalto G."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Cascio A."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Rubino R."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Colomba C."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Candore G."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Di Bona D."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Giannitrapani L."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Macchia L."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Tuttolomondo A."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Accardi G."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Bilancia M."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/author | "Caiaffa M.F."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/name | "J Viral Hepat"xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/pages | "768-775"xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/title | "KIR2DL3 and the KIR ligand groups HLA-A-Bw4 and HLA-C2 predict the outcome of hepatitis B virus infection."xsd:string |
| http://purl.uniprot.org/citations/28211154 | http://purl.uniprot.org/core/volume | "24"xsd:string |