| http://purl.uniprot.org/citations/28218426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28218426 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer stem cell (CSCs) has started a new era in cancer research. CD133 is a widely used marker for identification of CSCs. More and more studies showed that NK cells preferentially target cancer stem-like cells. However, the deeper mechanism of the susceptibility of cancer stem cells to NK cells remains unclear. In this study, we isolated CD133 positive population of a gastric cancer cell line, BGC823 cells, and cultured with NK cells. We found that CD133 could efficiently active NK cells in an NKG2D-dependent manner. DKK3 has been demonstrated as a suppressor in many cancers. Interestingly, we found that DKK3 suppressed CD133-induced activation in NK cells by inhibiting Erk pathway and immunological synapse (IS) formation. NK cells-based CSCs immunotherapy may be a novel approach for cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/28218426 | http://purl.org/dc/terms/identifier | "doi:10.1002/mc.22628"xsd:string |
| http://purl.uniprot.org/citations/28218426 | http://purl.uniprot.org/core/author | "Xu X.Y."xsd:string |
| http://purl.uniprot.org/citations/28218426 | http://purl.uniprot.org/core/author | "Xia P."xsd:string |
| http://purl.uniprot.org/citations/28218426 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28218426 | http://purl.uniprot.org/core/name | "Mol Carcinog"xsd:string |
| http://purl.uniprot.org/citations/28218426 | http://purl.uniprot.org/core/pages | "1712-1721"xsd:string |
| http://purl.uniprot.org/citations/28218426 | http://purl.uniprot.org/core/title | "DKK3 attenuates the cytotoxic effect of natural killer cells on CD133+ gastric cancer cells."xsd:string |
| http://purl.uniprot.org/citations/28218426 | http://purl.uniprot.org/core/volume | "56"xsd:string |
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