| http://purl.uniprot.org/citations/28219643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28219643 | http://www.w3.org/2000/01/rdf-schema#comment | "Colorectal cancer (CRC) is one of the most common malignancy, and the prognosis is not still satisfactory due to treatment resistance, recurrence and distant metastasis. Cancer stem cells (CSCs)/cancer-initiating cells (CICs) is endowed with higher tumor-initiating ability, self-renewal ability and differentiation ability, and CSCs/CICs are resistant to treatments. Thus, CSCs/CICs are thought to be responsible for recurrence and distant metastasis, and eradication of CSCs/CICs is essential to cure CRCs. However, the molecular mechanisms of CSCs/CICs are remain unknown, and we aimed to elucidate molecular aspects of CR-CSCs/CICs in this study. We screened the transcriptome data of primary human CR-CSCs/CICs that we previously established, and found that LEM domain containing 1 (LEMD1) is preferentially expressed in CR-CSCs/CICs. LEMD1 belongs to cancer-testis (CT) antigen, and has five transcript variants (variant 1 [V1] - variant 5 [V5]). We found that LEMD1 V1, V2 and V3 is expressed in testis and CR-CSCs/CICs, whereas LEMD1 V4 and V5 is ubiquitously expressed. LEMD1 gene knockdown experiments using siRNAs and gene overexpression experiments revealed that LEMD1 has a role in the maintenance of CR-CSCs/CICs. These observations indicate that CR-CSC/CIC-specific LEMD1 variants are reasonable target of CR-CSC/CIC-targeted therapy."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2017.02.081"xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Kubo T."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Ogawa T."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Sato N."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Shen M."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Yamamoto E."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Okita K."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Torigoe T."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Tsukahara T."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Nishidate T."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Takeda R."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Hirohashi Y."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Murai A."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Kanaseki T."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Nakatsugawa M."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Takemasa I."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/author | "Kutomi G."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/pages | "651-657"xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/title | "Identification and functional analysis of variants of a cancer/testis antigen LEMD1 in colorectal cancer stem-like cells."xsd:string |
| http://purl.uniprot.org/citations/28219643 | http://purl.uniprot.org/core/volume | "485"xsd:string |