| http://purl.uniprot.org/citations/28222623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28222623 | http://www.w3.org/2000/01/rdf-schema#comment | "Objectives We investigated the effects of CD100 on naïve CD8+ T cells during hepatitis C virus (HCV) infection after interferon-α (IFN-α) therapy to clarify the mechanism underlying the effect of IFN-α in enhancing the antiviral response. Methods The CD100 molecules on subsets of CD8+ T cells were analysed with flow cytometry. The effects of CD100-overexpressing naïve CD8+ T cells were determined with ELISAs and an MTT cytotoxicity assay. The role of CD100-CD72 signal transduction was analysed with a neutralization and transwell assays. Results HCV infection reduced CD100 expression on CD8+ T cells, whereas IFN-α treatment significantly increased CD100 expression on naïve CD8+ T cells. The increased CD100 interacted with the CD72 receptor and enhanced PBMC cytokine secretion (IFN-γ and tumour necrosis factor-α) and cytotoxicity. Conclusions IFN-α-induced CD100 on naïve CD8+ T cells promotes PBMC cytokine secretion and cytotoxicity through CD100-CD72 signalling during HCV infection."xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.org/dc/terms/identifier | "doi:10.1177/0300060516676136"xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/author | "Fan C."xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/author | "Li J.G."xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/author | "Guo Y.H."xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/author | "Zhao J.R."xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/author | "Li B.J."xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/author | "Zhang P.X."xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/author | "Jia Z.S."xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/author | "Zuo W.Z."xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/name | "J Int Med Res"xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/pages | "89-100"xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/title | "Interferon-alpha-induced CD100 on naive CD8pisup>+pi/sup> T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction."xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/28222623 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28222623 |
| http://purl.uniprot.org/citations/28222623 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28222623 |
| http://purl.uniprot.org/uniprot/#_A0A2D3E5G9-mappedCitation-28222623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28222623 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG45-mappedCitation-28222623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28222623 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUN5-mappedCitation-28222623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28222623 |