| http://purl.uniprot.org/citations/28223495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28223495 | http://www.w3.org/2000/01/rdf-schema#comment | "The rostral migratory stream (RMS) is viewed as a glia-enriched conduit of forward-migrating neuroblasts in which chemorepulsive signals control the pace of forward migration. Here we demonstrate the existence of a scaffold of neurons that receive synaptic inputs within the rat, mouse, and human fetal RMS equivalents. These neurons express secretagogin, a Ca2+-sensor protein, to execute an annexin V-dependent externalization of matrix metalloprotease-2 (MMP-2) for reconfiguring the extracellular matrix locally. Mouse genetics combined with pharmacological probing in vivo and in vitro demonstrate that MMP-2 externalization occurs on demand and that its loss slows neuroblast migration. Loss of function is particularly remarkable upon injury to the olfactory bulb. Cumulatively, we identify a signaling cascade that provokes structural remodeling of the RMS through recruitment of MMP-2 by a previously unrecognized neuronal constituent. Given the life-long presence of secretagogin-containing neurons in human, this mechanism might be exploited for therapeutic benefit in rescue strategies."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1700662114"xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Lubec G."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Wagner L."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Harkany T."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Tortoriello G."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Kovacs G.G."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Toth Z.E."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Szodorai E."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Puskar Z."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Alpar A."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Keimpema E."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Hokfelt T.G."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Malenczyk K."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Hanics J."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Lutz M.I."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Hevesi Z."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/author | "Kozsurek M."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/pages | "E2006-E2015"xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/title | "Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration."xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/28223495 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28223495 |