| http://purl.uniprot.org/citations/28224433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28224433 | http://www.w3.org/2000/01/rdf-schema#comment | "The HIV susceptibility and resistance alleles in the HLA genes were determined by investigating the distribution characteristics of the HLA alleles (A, B, and DRB1) in HIV-infected individuals of the Han population in Hubei, and by comparing these alleles with HIV-negative individuals from the same area. A cohort of 424 HIV-1 infected individuals were chosen as study subjects, and 836 HIV-negative healthy subjects from the same area served as the control population. HLA-A, B, and DRB1 allele typing was performed using polymerase chain reaction-sequence-specific oligonucleotide probes (PCR-SSOP) and polymerase chain reaction-sequencing based typing (PCR-SBT) techniques. Arlequin ver3.0 was used to analyze the allele and haplotype frequencies of HLA-A, B, and DRB 1, whereas Epi Info 7 and SPSS18.0 was used to analyze the differences in the HLA alleles between the HIV-1 positive and HIV-1 negative groups. A*02:03, DRB1*01:01, and DRB1*15:01 alleles and their haplotypes as well as the HLA_Bw4-Bw6 hybrid showed a protective effect on HIV-1 infection. After adjusting for confounding factors such as age and sex, multivariate logistic regression analysis revealed that B*15:02G, DRB1*01:01, and DRB1*15:01 subtypes were the resistance genes of HIV-1 infection, while B*13:01 might increase susceptibility to HIV-1 infection. The correlation between A*02:06 and B*15:01G subtypes and HIV-1 susceptibility was independent of the age and sex of the host. This study demonstrated the influence of genetic factors in humans such as HLA polymorphism on individuals to resist HIV-1 infection. Association studies of HLA polymorphism, susceptibility/resistance to HIV-1 infection, and hosts' genetic background are of significant importance for research on HIV-1 pathogenesis and vaccine design."xsd:string |
| http://purl.uniprot.org/citations/28224433 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11596-017-1706-z"xsd:string |
| http://purl.uniprot.org/citations/28224433 | http://purl.uniprot.org/core/author | "Ma Y."xsd:string |
| http://purl.uniprot.org/citations/28224433 | http://purl.uniprot.org/core/author | "Li W.X."xsd:string |
| http://purl.uniprot.org/citations/28224433 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/28224433 | http://purl.uniprot.org/core/author | "Shen G."xsd:string |
| http://purl.uniprot.org/citations/28224433 | http://purl.uniprot.org/core/author | "Xia J.A."xsd:string |
| http://purl.uniprot.org/citations/28224433 | http://purl.uniprot.org/core/author | "Qiu F.W."xsd:string |
| http://purl.uniprot.org/citations/28224433 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28224433 | http://purl.uniprot.org/core/name | "J Huazhong Univ Sci Technolog Med Sci"xsd:string |
| http://purl.uniprot.org/citations/28224433 | http://purl.uniprot.org/core/pages | "131-139"xsd:string |
| http://purl.uniprot.org/citations/28224433 | http://purl.uniprot.org/core/title | "Association of HLA alleles (A, B, DRB1) and HIV-1 infection in the Han population of Hubei, China."xsd:string |
| http://purl.uniprot.org/citations/28224433 | http://purl.uniprot.org/core/volume | "37"xsd:string |
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