| http://purl.uniprot.org/citations/28225209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28225209 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-10 (IL-10), a potent anti-inflammatory T-cell cytokine, has been shown to be a regulatory cytokine that is associated with disease remission in multiple sclerosis (MS) and exerts its activity through its cognate cell surface receptor complex, IL-10 receptor 1 (IL-10R1) and IL-10R2. The purpose of this study was to investigate the IL-10R1 S138G loss-of-function polymorphism (A536G: rs3135932) for possible influence on susceptibility and outcome of MS in Tunisian patients. A total of 103 Tunisian MS patients and 160 control subjects were studied. Genomic DNA samples were extracted from leukocytes and used to investigate S138G polymorphism in IL-10R1 gene by multiplex allele-specific polymerase chain reaction. Associations between G allele [odds ratio (OR) = 5.57; 95% confidence intervals (CI) = 3.26-9.54; p = 10-7 ], GG genotypes [OR = 10.41; 95% CI = 2.28-47.58; p = 0.0007] and AG genotype [OR = 4.14; 95% CI = 2.16-7.93; p = 0.000016] with the risk development of MS were found. In contrast, the AA genotype seemed to be associated with protection against MS [OR = 0.17; 95% CI = 0.09-0.30; p = 10-7 ]. No association was found between S138G SNP and clinical features or disease activity of MS patients. In conclusion, our results suggest that S138G loss-of-function polymorphism of the IL-10R1 may be important risk factor in increasing susceptibility to MS."xsd:string |
| http://purl.uniprot.org/citations/28225209 | http://purl.org/dc/terms/identifier | "doi:10.1111/apm.12659"xsd:string |
| http://purl.uniprot.org/citations/28225209 | http://purl.uniprot.org/core/author | "Aouni M."xsd:string |
| http://purl.uniprot.org/citations/28225209 | http://purl.uniprot.org/core/author | "Boukadida J."xsd:string |
| http://purl.uniprot.org/citations/28225209 | http://purl.uniprot.org/core/author | "Aissi M."xsd:string |
| http://purl.uniprot.org/citations/28225209 | http://purl.uniprot.org/core/author | "Mahmoud I."xsd:string |
| http://purl.uniprot.org/citations/28225209 | http://purl.uniprot.org/core/author | "Ben Selma W."xsd:string |
| http://purl.uniprot.org/citations/28225209 | http://purl.uniprot.org/core/author | "Nefzi F."xsd:string |
| http://purl.uniprot.org/citations/28225209 | http://purl.uniprot.org/core/author | "Ben Fredj N."xsd:string |
| http://purl.uniprot.org/citations/28225209 | http://purl.uniprot.org/core/author | "Frih-Ayed M."xsd:string |
| http://purl.uniprot.org/citations/28225209 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28225209 | http://purl.uniprot.org/core/name | "APMIS"xsd:string |
| http://purl.uniprot.org/citations/28225209 | http://purl.uniprot.org/core/pages | "444-451"xsd:string |
| http://purl.uniprot.org/citations/28225209 | http://purl.uniprot.org/core/title | "Association of the IL-10 receptor A536G (S138G) loss-of-function variant with multiple sclerosis in Tunisian patients."xsd:string |
| http://purl.uniprot.org/citations/28225209 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/28225209 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28225209 |
| http://purl.uniprot.org/citations/28225209 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28225209 |
| http://purl.uniprot.org/uniprot/#_B7ZA31-mappedCitation-28225209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28225209 |
| http://purl.uniprot.org/uniprot/#_B4DVW4-mappedCitation-28225209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28225209 |
| http://purl.uniprot.org/uniprot/#_B4DWD6-mappedCitation-28225209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28225209 |
| http://purl.uniprot.org/uniprot/#_B4DWE1-mappedCitation-28225209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28225209 |
| http://purl.uniprot.org/uniprot/#_B7ZAM7-mappedCitation-28225209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28225209 |
| http://purl.uniprot.org/uniprot/#_H2DF05-mappedCitation-28225209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28225209 |
| http://purl.uniprot.org/uniprot/#_Q13651-mappedCitation-28225209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28225209 |