| http://purl.uniprot.org/citations/28232744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28232744 | http://www.w3.org/2000/01/rdf-schema#comment | "The initial stages of T-cell differentiation are characterized by a progressive commitment to the T-cell lineage, a process that involves the loss of alternative (myelo-erythroid, NK, B) lineage potentials. Aberrant differentiation during these stages can result in T-cell acute lymphoblastic leukemia (T-ALL). However, the mechanisms regulating the initial stages of human T-cell differentiation are obscure. Through loss of function studies, we showed BCL11B, a transcription factor recurrently mutated T-ALL, is essential for T-lineage commitment, particularly the repression of NK and myeloid potentials, and the induction of T-lineage genes, during the initial stages of human T-cell differentiation. In gain of function studies, BCL11B inhibited growth of and induced a T-lineage transcriptional program in T-ALL cells. We found previously unknown differentiation stage-specific DNA binding of BCL11B at multiple T-lineage genes; target genes showed BCL11B-dependent expression, suggesting a transcriptional activator role for BCL11B at these genes. Transcriptional analyses revealed differences in the regulatory actions of BCL11B between human and murine thymopoiesis. Our studies show BCL11B is a key regulator of the initial stages of human T-cell differentiation and delineate the BCL11B transcriptional program, enabling the dissection of the underpinnings of normal T-cell differentiation and providing a resource for understanding dysregulations in T-ALL."xsd:string |
| http://purl.uniprot.org/citations/28232744 | http://purl.org/dc/terms/identifier | "doi:10.1038/leu.2017.70"xsd:string |
| http://purl.uniprot.org/citations/28232744 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/28232744 | http://purl.uniprot.org/core/author | "Kim Y.M."xsd:string |
| http://purl.uniprot.org/citations/28232744 | http://purl.uniprot.org/core/author | "Luong A."xsd:string |
| http://purl.uniprot.org/citations/28232744 | http://purl.uniprot.org/core/author | "Crooks G.M."xsd:string |
| http://purl.uniprot.org/citations/28232744 | http://purl.uniprot.org/core/author | "Ha V.L."xsd:string |
| http://purl.uniprot.org/citations/28232744 | http://purl.uniprot.org/core/author | "Casero D."xsd:string |
| http://purl.uniprot.org/citations/28232744 | http://purl.uniprot.org/core/author | "Bhatia R."xsd:string |
| http://purl.uniprot.org/citations/28232744 | http://purl.uniprot.org/core/author | "Malvar J."xsd:string |
| http://purl.uniprot.org/citations/28232744 | http://purl.uniprot.org/core/author | "Parekh C."xsd:string |
| http://purl.uniprot.org/citations/28232744 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28232744 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/28232744 | http://purl.uniprot.org/core/pages | "2503-2514"xsd:string |
| http://purl.uniprot.org/citations/28232744 | http://purl.uniprot.org/core/title | "The T-ALL related gene BCL11B regulates the initial stages of human T-cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/28232744 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/28232744 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28232744 |
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